Dtx4 MGI Mouse Gene Detail - MGI:2672905 - deltex 4, E3 ubiquitin ligase

Symbol

Dtx4
Name

deltex 4, E3 ubiquitin ligase
Synonyms

RNF155

Feature Type

protein coding gene
IDs

MGI:2672905
NCBI Gene: 207521
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr19:12443702-12478818 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.72 cM
Mapping Data

2 experiments

SNPs within 2kb

1043 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2672905	protein coding gene	Chr19:12443700-12479509 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024906	protein coding gene	Chr19:9926083-9967056 (-)
A/J	MGP_AJ_G0024882	protein coding gene	Chr19:9302939-9338716 (-)
AKR/J	MGP_AKRJ_G0024854	protein coding gene	Chr19:9763497-9799118 (-)
BALB/cJ	MGP_BALBcJ_G0024881	protein coding gene	Chr19:9302567-9339675 (-)
C3H/HeJ	MGP_C3HHeJ_G0024645	protein coding gene	Chr19:9651991-9687642 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025330	protein coding gene	Chr19:10469671-10511451 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022756	protein coding gene	Chr19:9938374-9974477 (-)
CAST/EiJ	MGP_CASTEiJ_G0024114	protein coding gene	Chr19:9227576-9265015 (-)
CBA/J	MGP_CBAJ_G0024619	protein coding gene	Chr19:10551855-10590082 (-)
DBA/2J	MGP_DBA2J_G0024751	protein coding gene	Chr19:9340187-9392469 (-)
FVB/NJ	MGP_FVBNJ_G0024714	protein coding gene	Chr19:9365442-9401699 (-)
LP/J	MGP_LPJ_G0024834	protein coding gene	Chr19:9998663-10042966 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024741	protein coding gene	Chr19:10333378-10369948 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025378	protein coding gene	Chr19:9743404-9779336 (-)
PWK/PhJ	MGP_PWKPhJ_G0023862	protein coding gene	Chr19:8789413-8844242 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023667	protein coding gene	Chr19:8879387-8914991 (-)
WSB/EiJ	MGP_WSBEiJ_G0024182	protein coding gene	Chr19:9603921-9640529 (-)

Human Ortholog

DTX4, deltex E3 ubiquitin ligase 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DTX4, deltex E3 ubiquitin ligase 4
Synonyms

RNF155
Links

HGNC:29151

NCBI Gene ID: 23220

neXtProt AC: NX_Q9Y2E6

UniProt: Q9Y2E6
Chr Location

11q12.1; chr11:59171430-59208588 (+) GRCh38

MGI Vertebrate Homology

Dtx4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DTX4
Gene Tree

Dtx4

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

850
Tissues

69
cDNA Data

111
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS29631.1

Ensembl

ENSMUSG00000039982 (Evidence)
NCBI Gene

207521

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039982	Ensembl Gene Model \| MGI Sequence Detail	35117	C57BL/6J	± kb
transcript	ENSMUST00000045521	Ensembl \| MGI Sequence Detail	5226	Not Applicable
polypeptide	ENSMUSP00000040229	Ensembl \| MGI Sequence Detail	616	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006724 E3 ubiquitin-protein ligase DTX4

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR039396 Deltex, C-terminal

IPR039399 Deltex, C-terminal domain superfamily

IPR039398 Deltex family

IPR004170 WWE domain

IPR018123 WWE domain, subgroup

IPR037197 WWE domain superfamily

IPR018957 Zinc finger, C3HC4 RING-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 113

cDNA 112

Primer pair 1

Microarray probesets 4

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MGI:2147542

Summaries

All 43

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 7
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dtx4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158433	Chr19:12479446-12479516 (-)	-663 bp
Tssr5450	Chr19:12479428-12479443 (-)	-618 bp
Tssr158432	Chr19:12479299-12479337 (-)	-500 bp
Tssr158431	Chr19:12479266-12479295 (-)	-463 bp
Tssr158430	Chr19:12479213-12479235 (-)	-406 bp
Tssr158429	Chr19:12479200-12479211 (-)	-388 bp
Tssr158428	Chr19:12479177-12479186 (-)	-364 bp
Tssr158427	Chr19:12478997-12479036 (-)	-199 bp
Tssr158426	Chr19:12478911-12478994 (-)	-135 bp
Tssr158425	Chr19:12478842-12478869 (-)	-38 bp
Tssr158424	Chr19:12478804-12478818 (-)	7 bp
Tssr158423	Chr19:12469302-12469347 (-)	9,493 bp
Tssr158422	Chr19:12464404-12464424 (-)	14,404 bp
Tssr158421	Chr19:12454330-12454343 (-)	24,481 bp
Tssr158420	Chr19:12450788-12450797 (-)	28,025 bp
Tssr158419	Chr19:12450688-12450712 (-)	28,118 bp
Tssr158418	Chr19:12446424-12446429 (-)	32,391 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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