Trim46 MGI Mouse Gene Detail - MGI:2673000 - tripartite motif-containing 46

Symbol

Trim46
Name

tripartite motif-containing 46
Synonyms

TRIFIC

Feature Type

protein coding gene
IDs

MGI:2673000
NCBI Gene: 360213
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:89141484-89153616 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.02 cM
Mapping Data

2 experiments

SNPs within 2kb

326 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2673000	protein coding gene	Chr3:89141476-89153655 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027425	protein coding gene	Chr3:89437568-89451898 (-)
A/J	MGP_AJ_G0027389	protein coding gene	Chr3:86479321-86491510 (-)
AKR/J	MGP_AKRJ_G0027353	protein coding gene	Chr3:88569794-88581886 (-)
BALB/cJ	MGP_BALBcJ_G0027398	protein coding gene	Chr3:86443061-86455202 (-)
C3H/HeJ	MGP_C3HHeJ_G0027140	protein coding gene	Chr3:88770679-88783912 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027844	protein coding gene	Chr3:92822196-92836524 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025196	protein coding gene	Chr3:81959094-81971408 (-)
CAST/EiJ	MGP_CASTEiJ_G0026586	protein coding gene	Chr3:89121968-89134173 (-)
CBA/J	MGP_CBAJ_G0027114	protein coding gene	Chr3:96000609-96012661 (-)
DBA/2J	MGP_DBA2J_G0027252	protein coding gene	Chr3:85857767-85869916 (-)
FVB/NJ	MGP_FVBNJ_G0027220	protein coding gene	Chr3:84198586-84210691 (-)
LP/J	MGP_LPJ_G0027361	protein coding gene	Chr3:90516301-90529637 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027240	protein coding gene	Chr3:102222679-102235897 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027903	protein coding gene	Chr3:88321161-88333256 (-)
PWK/PhJ	MGP_PWKPhJ_G0026320	protein coding gene	Chr3:85730307-85743007 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026139	protein coding gene	Chr3:87490528-87504227 (-)
WSB/EiJ	MGP_WSBEiJ_G0026668	protein coding gene	Chr3:88714055-88727933 (-)

Human Ortholog

TRIM46, tripartite motif containing 46

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM46, tripartite motif containing 46
Synonyms

GENEY, TRIFIC
Links

HGNC:19019

NCBI Gene ID: 80128

neXtProt AC: NX_Q7Z4K8

UniProt: Q7Z4K8
Chr Location

1q22; chr1:155173787-155184971 (+) GRCh38

MGI Vertebrate Homology

Trim46 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRIM46
Gene Tree

Trim46

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Radiation induced

1
Genomic Mutations

2 involving Trim46
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

28
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

ZFIN trim46a

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All Sequences

78
RefSeq

28
UniProt

6
CCDS

CCDS17497.1, CCDS17498.1

Ensembl

ENSMUSG00000042766 (Evidence)
NCBI Gene

360213

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042766	Ensembl Gene Model \| MGI Sequence Detail	12133	C57BL/6J	± kb
transcript	ENSMUST00000041022	Ensembl \| MGI Sequence Detail	3122	Not Applicable
polypeptide	ENSMUSP00000036053	Ensembl \| MGI Sequence Detail	759	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000030277 tripartite motif-containing protein 46

(term hierarchy)
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR000315 B-box-type zinc finger

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR017903 COS domain

IPR050617 E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR040859 Midline-1, COS domain

IPR035731 TRIM46, PRY/SPRY domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 10

cDNA 10

Microarray probesets 2

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MGI:2139686

Summaries

All 37

Developmental Gene Expression 1

Diseases 1

Gene Ontology 7

Phenotypes 11
Earliest

J:29857 Vos HL, et al., A tightly organized, conserved gene cluster on mouse chromosome 3 (E3-F1). Mamm Genome. 1995 Nov;6(11):820-2
Latest

J:357972 Melton AJ, et al., TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation. J Neurosci. 2024 Oct 16;44(42)

TSS for Trim46:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34107	Chr3:89153136-89153206 (-)	445 bp
Tssr34106	Chr3:89153118-89153132 (-)	491 bp
Tssr939	Chr3:89152534-89152570 (-)	1,064 bp
Tssr34105	Chr3:89152466-89152500 (-)	1,133 bp
Tssr34104	Chr3:89152312-89152338 (-)	1,291 bp
Tssr34103	Chr3:89146750-89146786 (-)	6,848 bp
Tssr34102	Chr3:89146008-89146043 (-)	7,590 bp
Tssr938	Chr3:89145713-89145757 (-)	7,881 bp
Tssr34101	Chr3:89145234-89145247 (-)	8,375 bp
Tssr34100	Chr3:89145144-89145152 (-)	8,468 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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