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Frat2 Gene Detail
Summary
  • Symbol
    Frat2
  • Name
    frequently rearranged in advanced T cell lymphomas 2
  • Synonyms
    MGC:37615
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673967
    NCBI Gene: 212398
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41834411-41836571 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 35.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673967
 protein coding gene Chr19:41834411-41836571 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025128
 protein coding gene Chr19:41139144-41141298 (-)
A/J MGP_AJ_G0025105
 protein coding gene Chr19:39161252-39164255 (-)
AKR/J MGP_AKRJ_G0025073
 protein coding gene Chr19:40454997-40457151 (-)
BALB/cJ MGP_BALBcJ_G0025099
 protein coding gene Chr19:39222690-39224844 (-)
C3H/HeJ MGP_C3HHeJ_G0024859
 protein coding gene Chr19:40602650-40604804 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025543
 protein coding gene Chr19:42224428-42226555 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022956
 protein coding gene Chr19:38521002-38523224 (-)
CAST/EiJ MGP_CASTEiJ_G0024324
 protein coding gene Chr19:40268816-40270967 (-)
CBA/J MGP_CBAJ_G0024839
 protein coding gene Chr19:44271438-44273592 (-)
DBA/2J MGP_DBA2J_G0024971
 protein coding gene Chr19:39012698-39014825 (-)
FVB/NJ MGP_FVBNJ_G0024932
 protein coding gene Chr19:38788430-38790584 (-)
LP/J MGP_LPJ_G0025057
 protein coding gene Chr19:41135711-41137865 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024963
 protein coding gene Chr19:43900424-43902578 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025600
 protein coding gene Chr19:40489641-40492056 (-)
PWK/PhJ MGP_PWKPhJ_G0024074
 protein coding gene Chr19:38889396-38891538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023877
 protein coding gene Chr19:39235836-39237988 (-)
WSB/EiJ MGP_WSBEiJ_G0024394
 protein coding gene Chr19:40640888-40643043 (-)



Homology
more
  • Human Ortholog
    FRAT2, FRAT regulator of WNT signaling pathway 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRAT2, FRAT regulator of WNT signaling pathway 2
  • Synonyms
    FRAT-2
  • Links
    NCBI Gene ID: 23401
    neXtProt AC: NX_O75474
    UniProt: O75474

  • Chr Location
    10q24.1; chr10:97332497-97334729 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    3 phenotype references
Homozygous mice are healthy and fertile with no obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    192
  • cDNA Data
    21
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 212398 NCBI Gene Model | MGI Sequence Detail 2161 C57BL/6J ±  kb
transcript NM_177603 RefSeq | MGI Sequence Detail 2176 ZRU/MplStud  
polypeptide Q8K025 UniProt | EBI | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR008014 Glycogen synthase kinase-3 binding protein
Molecular
Reagents
less
  • All nucleic 25
    cDNA 21
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:291575 van der Wal T, et al., TMEM98 is a negative regulator of FRAT mediated Wnt/ss-catenin signalling. PLoS One. 2020;15(1):e0227435
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory