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Nlrp9b Gene Detail
Summary
  • Symbol
    Nlrp9b
  • Name
    NLR family, pyrin domain containing 9B
  • Synonyms
    Nalp9b, Nalp-delta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675377
    NCBI Gene: 243874
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19725318-19796867 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1870 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675377
 protein coding gene Chr7:19725318-19807231 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031805
 protein coding gene Chr7:18081015-18130132 (+)
A/J MGP_AJ_G0031781
 protein coding gene Chr7:17690834-17734651 (+)
AKR/J MGP_AKRJ_G0031707
 protein coding gene Chr7:18182570-18223126 (+)
BALB/cJ MGP_BALBcJ_G0031786
 protein coding gene Chr7:17870277-17937564 (+)
C3H/HeJ MGP_C3HHeJ_G0031508
 protein coding gene Chr7:18426940-18462267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032252
 protein coding gene Chr7:18990108-19046459 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029318
 protein coding gene Chr7:19305768-19340175 (+)
CAST/EiJ MGP_CASTEiJ_G0030851
 protein coding gene Chr7:14891445-14946398 (+)
CBA/J MGP_CBAJ_G0031470
 protein coding gene Chr7:19667790-19701957 (+)
DBA/2J MGP_DBA2J_G0031625
 protein coding gene Chr7:17618408-17653769 (+)
FVB/NJ MGP_FVBNJ_G0031577
 protein coding gene Chr7:17501835-17539321 (+)
LP/J MGP_LPJ_G0031707
 protein coding gene Chr7:18405996-18451583 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031613
 protein coding gene Chr7:19489503-19544590 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032280
 protein coding gene Chr7:17790608-17831174 (+)
PWK/PhJ MGP_PWKPhJ_G0030574
 protein coding gene Chr7:14734435-14786332 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030951
 protein coding gene Chr7:18018594-18046397 (+)



Homology
more
  • Human Ortholog
    NLRP9, NLR family pyrin domain containing 9
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP9, NLR family pyrin domain containing 9
  • Synonyms
    CLR19.1, NALP9, NOD6, PAN12
  • Links
    NCBI Gene ID: 338321
    neXtProt AC: NX_Q7RTR0
    UniProt: Q7RTR0

  • Chr Location
    19q13.42; chr19:55708438-55738402 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The protein protects against rotavirus infection. Homozygous KO leads to increased susceptibility to infection and greater severity of pathology. Mice homozygous for null alleles of Nlrp9a, Nlrp9b, and Nlrp9c exhibit reduced litter size, incomplete preimplantation lethality, delayed or impaired blastocyst formation, and failure of cell division at the 2 cell stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    30
  • cDNA Data
    17
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243874 NCBI Gene Model | MGI Sequence Detail 71550 C57BL/6J ±  kb
    transcript NM_194058 RefSeq | MGI Sequence Detail 3346 C57BL/6  
    polypeptide Q66X22 UniProt | EBI | MGI Sequence Detail 1003 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011569 NACHT, LRR and PYD domains-containing protein 9B
      (term hierarchy)
    • InterPro Domains
      IPR004020 DAPIN domain
      IPR011029 Death-like domain superfamily
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
      IPR007111 NACHT nucleoside triphosphatase
      IPR050637 NLRP family, innate immunity and inflammation regulators
      IPR041075 NOD2, winged helix domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:93029 Dade S, et al., In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Biochem Biophys Res Commun. 2004 Nov 12;324(2):547-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory