Adig MGI Mouse Gene Detail - MGI:2675492

Symbol

Adig
Name

adipogenin
Synonyms

SMAF1

Feature Type

protein coding gene
IDs

MGI:2675492
NCBI Gene: 246747
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:158344532-158350118 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.72 cM
Mapping Data

1 experiment

SNPs within 2kb

315 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2675492	protein coding gene	Chr2:158344532-158350118 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026795	protein coding gene	Chr2:163580087-163585670 (+)
A/J	MGP_AJ_G0026761	protein coding gene	Chr2:157016645-157022223 (+)
AKR/J	MGP_AKRJ_G0026732	protein coding gene	Chr2:161643133-161648713 (+)
BALB/cJ	MGP_BALBcJ_G0026770	protein coding gene	Chr2:157322533-157328124 (+)
C3H/HeJ	MGP_C3HHeJ_G0026512	protein coding gene	Chr2:161993061-161998643 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027219	protein coding gene	Chr2:168461465-168467049 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024589	protein coding gene	Chr2:150458432-150464001 (+)
CAST/EiJ	MGP_CASTEiJ_G0025974	protein coding gene	Chr2:162334954-162341263 (+)
CBA/J	MGP_CBAJ_G0026489	protein coding gene	Chr2:174489097-174494672 (+)
DBA/2J	MGP_DBA2J_G0026627	protein coding gene	Chr2:156193530-156199112 (+)
FVB/NJ	MGP_FVBNJ_G0026594	protein coding gene	Chr2:154603033-154608617 (+)
LP/J	MGP_LPJ_G0026730	protein coding gene	Chr2:163671025-163676608 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026615	protein coding gene	Chr2:178281323-178286903 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027275	protein coding gene	Chr2:161474568-161480146 (+)
PWK/PhJ	MGP_PWKPhJ_G0025708	protein coding gene	Chr2:155728434-155734067 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025511	protein coding gene	Chr2:160396402-160401898 (+)
WSB/EiJ	MGP_WSBEiJ_G0026044	protein coding gene	Chr2:162368660-162374245 (+)

Human Ortholog

ADIG, adipogenin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADIG, adipogenin
Synonyms

SMAF1
Links

HGNC:28606

NCBI Gene ID: 149685

neXtProt AC: NX_Q0VDE8

UniProt: Q0VDE8
Chr Location

20q11.23; chr20:38581195-38588463 (+) GRCh38

MGI Vertebrate Homology

Adig stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ADIG
Gene Tree

Adig

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Phenotype Summary

18 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced high fat diet-induced fat and weight gain, decreased fat mass-adjusted leptin levels, and reduced leptin secretion in adipose explants.

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All GO Annotations

14
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

6
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS16990.1

Ensembl

ENSMUSG00000044405 (Evidence)
NCBI Gene

246747

			Length	Strain/Species	Flank
genomic	246747	NCBI Gene Model \| MGI Sequence Detail	5587	C57BL/6J	± kb
transcript	NM_145635	RefSeq \| MGI Sequence Detail	665	C57BL/6
polypeptide	Q8R400	UniProt \| EBI \| MGI Sequence Detail	80	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003776 adipogenin

(term hierarchy)
InterPro Domains

IPR027938 Adipogenin

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All nucleic 13

cDNA 13

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:86344 Pang AL, et al., Identification of differentially expressed genes in mouse spermatogenesis. J Androl. 2003 Nov-Dec;24(6):899-911
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adig:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21350	Chr2:158344457-158344472 (+)	-67 bp
Tssr21351	Chr2:158344497-158344506 (+)	-30 bp
Tssr21352	Chr2:158344535-158344552 (+)	12 bp
Tssr21353	Chr2:158344553-158344618 (+)	54 bp
Tssr21354	Chr2:158344628-158344640 (+)	102 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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