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Gzmn Gene Detail
Summary
  • Symbol
    Gzmn
  • Name
    granzyme N
  • Synonyms
    GrN
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675494
    NCBI Gene: 245839
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56403254-56412056 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    422 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675494
 protein coding gene Chr14:56403243-56412069 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021388
 protein coding gene Chr14:50246476-50255271 (-)
A/J MGP_AJ_G0021347
 protein coding gene Chr14:49257360-49266146 (-)
AKR/J MGP_AKRJ_G0021323
 protein coding gene Chr14:51027466-51039104 (-)
BALB/cJ MGP_BALBcJ_G0021350
 protein coding gene Chr14:49240133-49265775 (-)
C3H/HeJ MGP_C3HHeJ_G0021131
 protein coding gene Chr14:50684817-50693616 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021790
 protein coding gene Chr14:52780275-52789503 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019332
 protein coding gene Chr14:47451657-47460643 (-)
CAST/EiJ MGP_CASTEiJ_G0020650
 protein coding gene Chr14:46983830-46992557 (-)
CBA/J MGP_CBAJ_G0021098
 protein coding gene Chr14:54322059-54330841 (-)
DBA/2J MGP_DBA2J_G0021218
 protein coding gene Chr14:48970845-48979552 (-)
FVB/NJ MGP_FVBNJ_G0021201
 protein coding gene Chr14:48394371-48403138 (-)
LP/J MGP_LPJ_G0021293
 protein coding gene Chr14:51295389-51325293 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021225
 protein coding gene Chr14:53686995-53712579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021816
 protein coding gene Chr14:50184022-50192800 (-)
PWK/PhJ MGP_PWKPhJ_G0020393
 protein coding gene Chr14:45494005-45503064 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020223
 protein coding gene Chr14:46250919-46259646 (-)
WSB/EiJ MGP_WSBEiJ_G0020702
 protein coding gene Chr14:50486957-50503688 (-)



Homology
more
  • Human Ortholog
    GZMB, granzyme B
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GZMB, granzyme B
  • Synonyms
    C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
  • Links
    NCBI Gene ID: 3002
    neXtProt AC: NX_P10144
    UniProt: P10144

  • Chr Location
    14q12; chr14:24630954-24634267 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    14
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015443 Ensembl Gene Model | MGI Sequence Detail 8803 C57BL/6J ±  kb
transcript ENSMUST00000015587 Ensembl | MGI Sequence Detail 956 Not Applicable  
polypeptide ENSMUSP00000015587 Ensembl | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:85357 Sattar R, et al., Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling. Biochem Biophys Res Commun. 2003 Sep 5;308(4):726-35
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory