Trpm6 MGI Mouse Gene Detail - MGI:2675603 - transient receptor potential cation channel, subfamily M, member 6

Symbol

Trpm6
Name

transient receptor potential cation channel, subfamily M, member 6
Synonyms

CHAK2

Feature Type

protein coding gene
IDs

MGI:2675603
NCBI Gene: 225997
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:18727347-18869875 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 13.21 cM
Mapping Data

1 experiment

SNPs within 2kb

5046 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2675603	protein coding gene	Chr19:18707566-18869885 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024970	protein coding gene	Chr19:16645046-16792702 (+)
A/J	MGP_AJ_G0024947	protein coding gene	Chr19:15698919-15845092 (+)
AKR/J	MGP_AKRJ_G0024917	protein coding gene	Chr19:16323295-16472564 (+)
BALB/cJ	MGP_BALBcJ_G0024946	protein coding gene	Chr19:15732309-15875881 (+)
C3H/HeJ	MGP_C3HHeJ_G0024704	protein coding gene	Chr19:16264028-16416624 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025388	protein coding gene	Chr19:17230082-17384733 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022807	protein coding gene	Chr19:16067320-16219583 (+)
CAST/EiJ	MGP_CASTEiJ_G0024172	protein coding gene	Chr19:15909041-16063029 (+)
CBA/J	MGP_CBAJ_G0024682	protein coding gene	Chr19:17853482-18033482 (+)
DBA/2J	MGP_DBA2J_G0024814	protein coding gene	Chr19:15729323-15871541 (+)
FVB/NJ	MGP_FVBNJ_G0024775	protein coding gene	Chr19:15645217-15783825 (+)
LP/J	MGP_LPJ_G0024898	protein coding gene	Chr19:16606556-16756743 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024802	protein coding gene	Chr19:17741244-17898367 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025443	protein coding gene	Chr19:16263746-16417718 (+)
PWK/PhJ	MGP_PWKPhJ_G0023921	protein coding gene	Chr19:15275560-15428409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023726	protein coding gene	Chr19:15562255-15724519 (+)
WSB/EiJ	MGP_WSBEiJ_G0024240	protein coding gene	Chr19:16312144-16472979 (+)

Human Ortholog

TRPM6, transient receptor potential cation channel subfamily M member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRPM6, transient receptor potential cation channel subfamily M member 6
Synonyms

CHAK2, HMGX, HOMG, HOMG1, HSH
Links

HGNC:17995

NCBI Gene ID: 140803

neXtProt AC: NX_Q9BX84

UniProt: Q9BX84
Chr Location

9q21.13; chr9:74722495-74888094 (-) GRCh38

MGI Vertebrate Homology

Trpm6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRPM6
Gene Tree

Trpm6

Diseases

2 with human TRPM6 associations

				Human Disease	Mouse Models
				intestinal hypomagnesemia 1 IDs intestinal hypomagnesemia 1 DOID:0060883 ICD10CM:E83.4 OMIM:602014 ORDO:30924
				metal metabolism disorder IDs metal metabolism disorder DOID:896 MESH:D008664 UMLS_CUI:C0025534

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

111 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic and postnatal lethality with exencephaly, spina bifida occulta, and abnormal brain and facial development. Mice heterozygous for a knock-out allele exhibit some premature death and decreased serummagnesium.

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All GO Annotations

45
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

36
cDNA Data

23
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trpm6

ZFIN trpm6

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All Sequences

58
RefSeq

21
UniProt

3
CCDS

CCDS29691.1

Ensembl

ENSMUSG00000024727 (Evidence)
NCBI Gene

225997

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024727	Ensembl Gene Model \| MGI Sequence Detail	142529	C57BL/6J	± kb
transcript	ENSMUST00000040489	Ensembl \| MGI Sequence Detail	6509	Not Applicable
polypeptide	ENSMUSP00000037443	Ensembl \| MGI Sequence Detail	2028	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016702 transient receptor potential cation channel subfamily M member 6

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR004166 Alpha-type protein kinase, alpha-kinase domain

IPR005821 Ion transport domain

IPR011009 Protein kinase-like domain superfamily

IPR050927 Transient receptor potential cation channel M

IPR029597 Transient receptor potential cation channel subfamily M member 6, alpha-kinase domain

IPR041491 TRPM, SLOG domain

IPR032415 TRPM, tetramerisation domain

IPR037162 TRPM, tetramerisation domain superfamily

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All nucleic 28

cDNA 23

Primer pair 4

Other 1

Microarray probesets 3

Summaries

All 52

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 14
Earliest

J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
Latest

J:358544 Adella A, et al., Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment. Pflugers Arch. 2024 Sep 13;

TSS for Trpm6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155459	Chr19:18727088-18727107 (+)	-249 bp
Tssr155460	Chr19:18727109-18727132 (+)	-226 bp
Tssr155461	Chr19:18735971-18736009 (+)	8,643 bp
Tssr155462	Chr19:18753536-18753546 (+)	26,194 bp
Tssr155463	Chr19:18817970-18817982 (+)	90,629 bp
Tssr155464	Chr19:18818004-18818013 (+)	90,662 bp
Tssr155465	Chr19:18833032-18833036 (+)	105,687 bp
Tssr5456	Chr19:18865453-18865457 (+)	138,108 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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