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Trpm6 Gene Detail
Summary
  • Symbol
    Trpm6
  • Name
    transient receptor potential cation channel, subfamily M, member 6
  • Synonyms
    CHAK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675603
    NCBI Gene: 225997
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:18727347-18869875 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5046 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675603
 protein coding gene Chr19:18707566-18869885 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024970
 protein coding gene Chr19:16645046-16792702 (+)
A/J MGP_AJ_G0024947
 protein coding gene Chr19:15698919-15845092 (+)
AKR/J MGP_AKRJ_G0024917
 protein coding gene Chr19:16323295-16472564 (+)
BALB/cJ MGP_BALBcJ_G0024946
 protein coding gene Chr19:15732309-15875881 (+)
C3H/HeJ MGP_C3HHeJ_G0024704
 protein coding gene Chr19:16264028-16416624 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025388
 protein coding gene Chr19:17230082-17384733 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022807
 protein coding gene Chr19:16067320-16219583 (+)
CAST/EiJ MGP_CASTEiJ_G0024172
 protein coding gene Chr19:15909041-16063029 (+)
CBA/J MGP_CBAJ_G0024682
 protein coding gene Chr19:17853482-18033482 (+)
DBA/2J MGP_DBA2J_G0024814
 protein coding gene Chr19:15729323-15871541 (+)
FVB/NJ MGP_FVBNJ_G0024775
 protein coding gene Chr19:15645217-15783825 (+)
LP/J MGP_LPJ_G0024898
 protein coding gene Chr19:16606556-16756743 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024802
 protein coding gene Chr19:17741244-17898367 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025443
 protein coding gene Chr19:16263746-16417718 (+)
PWK/PhJ MGP_PWKPhJ_G0023921
 protein coding gene Chr19:15275560-15428409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023726
 protein coding gene Chr19:15562255-15724519 (+)
WSB/EiJ MGP_WSBEiJ_G0024240
 protein coding gene Chr19:16312144-16472979 (+)



Homology
more
  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
  • Synonyms
    CHAK2, HMGX, HOMG, HOMG1, HSH
  • Links
    NCBI Gene ID: 140803
    neXtProt AC: NX_Q9BX84
    UniProt: Q9BX84

  • Chr Location
    9q21.13; chr9:74722495-74888094 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TRPM6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic and postnatal lethality with exencephaly, spina bifida occulta, and abnormal brain and facial development. Mice heterozygous for a knock-out allele exhibit some premature death and decreased serummagnesium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    36
  • cDNA Data
    23
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024727 Ensembl Gene Model | MGI Sequence Detail 142529 C57BL/6J ±  kb
    transcript ENSMUST00000040489 Ensembl | MGI Sequence Detail 6509 Not Applicable  
    polypeptide ENSMUSP00000037443 Ensembl | MGI Sequence Detail 2028 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000016702 transient receptor potential cation channel subfamily M member 6
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR004166 Alpha-type protein kinase, alpha-kinase domain
      IPR005821 Ion transport domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050927 Transient receptor potential cation channel M
      IPR029597 Transient receptor potential cation channel subfamily M member 6, alpha-kinase domain
      IPR041491 TRPM, SLOG domain
      IPR032415 TRPM, tetramerisation domain
      IPR037162 TRPM, tetramerisation domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 23
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory