Wapl MGI Mouse Gene Detail - MGI:2675859 - WAPL cohesin release factor

Symbol

Wapl
Name

WAPL cohesin release factor
Synonyms

A530089A20Rik, mKIAA0261, Wapal

Feature Type

protein coding gene
IDs

MGI:2675859
NCBI Gene: 218914
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr14:34395885-34469940 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.84 cM
Mapping Data

1 experiment

SNPs within 2kb

1094 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2675859	protein coding gene	Chr14:34394086-34469940 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021179	protein coding gene	Chr14:28039731-28111318 (+)
A/J	MGP_AJ_G0021127	protein coding gene	Chr14:26971278-27040691 (+)
AKR/J	MGP_AKRJ_G0021104	protein coding gene	Chr14:28151791-28227064 (+)
BALB/cJ	MGP_BALBcJ_G0021131	protein coding gene	Chr14:27142000-27214356 (+)
C3H/HeJ	MGP_C3HHeJ_G0020914	protein coding gene	Chr14:28086517-28164842 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021563	protein coding gene	Chr14:29113753-29194025 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019125	protein coding gene	Chr14:26974199-27040811 (+)
CAST/EiJ	MGP_CASTEiJ_G0020439	protein coding gene	Chr14:27895378-27971794 (+)
CBA/J	MGP_CBAJ_G0020880	protein coding gene	Chr14:30186207-30264355 (+)
DBA/2J	MGP_DBA2J_G0021003	protein coding gene	Chr14:26997535-27063144 (+)
FVB/NJ	MGP_FVBNJ_G0020987	protein coding gene	Chr14:26955961-27030602 (+)
LP/J	MGP_LPJ_G0021072	protein coding gene	Chr14:28368207-28439887 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021013	protein coding gene	Chr14:29303918-29400549 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021596	protein coding gene	Chr14:27996242-28078922 (+)
PWK/PhJ	MGP_PWKPhJ_G0020187	protein coding gene	Chr14:26480470-26552330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020011	protein coding gene	Chr14:27592963-27662227 (+)
WSB/EiJ	MGP_WSBEiJ_G0020494	protein coding gene	Chr14:28039192-28120236 (+)

Human Ortholog

WAPL, WAPL cohesin release factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WAPL, WAPL cohesin release factor
Synonyms

FOE, KIAA0261, WAPAL
Links

HGNC:23293

NCBI Gene ID: 23063

neXtProt AC: NX_Q7Z5K2

UniProt: Q7Z5K2
Chr Location

10q23.2; chr10:86435256-86521792 (-) GRCh38

MGI Vertebrate Homology

Wapl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WAPL
Gene Tree

Wapl

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Phenotype Summary

6 phenotypes from 4 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

97
Endonuclease-mediated

3
Gene trapped

90
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

169 strains or lines available

Mice homozygous for a targeted allele exhibit prenatal lethality.

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All GO Annotations

27
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

96
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wapl

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All Sequences

69
RefSeq

6
UniProt

4
CCDS

CCDS36880.1, CCDS79296.1

Ensembl

ENSMUSG00000041408 (Evidence)
NCBI Gene

218914

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041408	Ensembl Gene Model \| MGI Sequence Detail	74056	C57BL/6J	± kb
transcript	ENSMUST00000169910	Ensembl \| MGI Sequence Detail	4066	Not Applicable
polypeptide	ENSMUSP00000130547	Ensembl \| MGI Sequence Detail	1200	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017368 wings apart-like protein

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR012502 WAPL domain

IPR039874 Wings apart-like protein

IPR022771 Wings apart-like protein, C-terminal
GlyGen

Q65Z40 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 14

cDNA 14

Microarray probesets 9

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MGI:2443602

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 16
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:337208 Kiefer L, et al., WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring. Science. 2023 Jun 23;380(6651):eadf8440

TSS for Wapl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125083	Chr14:34395824-34395841 (+)	-52 bp
Tssr125084	Chr14:34395845-34395887 (+)	-19 bp
Tssr125085	Chr14:34395905-34395922 (+)	29 bp
Tssr125086	Chr14:34395953-34395971 (+)	77 bp
Tssr125087	Chr14:34396011-34396022 (+)	132 bp
Tssr125088	Chr14:34396109-34396162 (+)	251 bp
Tssr125089	Chr14:34396163-34396189 (+)	291 bp
Tssr125090	Chr14:34399032-34399047 (+)	3,155 bp
Tssr125091	Chr14:34414487-34414500 (+)	18,609 bp
Tssr125092	Chr14:34416244-34416267 (+)	20,371 bp
Tssr125093	Chr14:34416958-34416970 (+)	21,079 bp
Tssr125094	Chr14:34422685-34422693 (+)	26,804 bp
Tssr125095	Chr14:34431825-34431829 (+)	35,942 bp
Tssr125096	Chr14:34436882-34436892 (+)	41,002 bp
Tssr125097	Chr14:34468793-34468798 (+)	72,911 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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