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Adam6a Gene Detail
Summary
  • Symbol
    Adam6a
  • Name
    a disintegrin and metallopeptidase domain 6A
  • Synonyms
    Adam6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676316
    NCBI Gene: 238406
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:113507528-113510034 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676316
 protein coding gene Chr12:113507528-113510085 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020177
 protein coding gene Chr12:116099710-116102410 (+)
A/J MGP_AJ_G0020132
 protein coding gene Chr12:111549085-111551784 (+)
AKR/J MGP_AKRJ_G0020107
 protein coding gene Chr12:114840892-114843485 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0019919
 protein coding gene Chr12:115307253-115377670 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020562
 protein coding gene Chr12:119645300-119647893 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0019459
 protein coding gene Chr12:110256293-110259775 (+)
CBA/J MGP_CBAJ_G0019886
 protein coding gene Chr12:124230697-124233705 (+)
DBA/2J MGP_DBA2J_G0020004
 protein coding gene Chr12:111113843-111116540 (+)
FVB/NJ MGP_FVBNJ_G0019989
 protein coding gene Chr12:109920336-109923034 (+)
LP/J MGP_LPJ_G0020077
 protein coding gene Chr12:115895458-115898051 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0020591
 protein coding gene Chr12:114291681-114294383 (+)
PWK/PhJ MGP_PWKPhJ_G0019222
 protein coding gene Chr12:105769702-105776443 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019025
 protein coding gene Chr12:108476750-108479001 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ADAM6, ADAM metallopeptidase domain 6 (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM6, ADAM metallopeptidase domain 6 (pseudogene)
  • Synonyms
    C14orf96, tMDCIV
  • Links
    NCBI Gene ID: 8755

  • Chr Location
    14q32.33; chr14:105969729-105972269 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    5 phenotype references
Mice homozygous for null alleles of Adam6a and Adam6b exhibit severely reduced male fertility associated with impaired sperm to sperm interactions and sperm binding to zona pellucida.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 238406 NCBI Gene Model | MGI Sequence Detail 2507 C57BL/6J ±  kb
transcript NM_174885 RefSeq | MGI Sequence Detail 2507 C57BL/6  
polypeptide NP_777479 RefSeq | MGI Sequence Detail 754 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:89726 Choi I, et al., Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Genomics. 2004 Apr;83(4):636-46
  • Latest
    J:284593 Skokos D, et al., A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies. Sci Transl Med. 2020 Jan 8;12(525)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory