L3mbtl1 MGI Mouse Gene Detail - MGI:2676663 - L3MBTL1 histone methyl-lysine binding protein

Symbol

L3mbtl1
Name

L3MBTL1 histone methyl-lysine binding protein
Synonyms

L3MBTL1

Feature Type

protein coding gene
IDs

MGI:2676663
NCBI Gene: 241764
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:162785392-162816442 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 83.88 cM
Mapping Data

1 experiment

SNPs within 2kb

1115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676663	protein coding gene	Chr2:162784260-162819726 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026814	protein coding gene	Chr2:168222629-168258772 (+)
A/J	MGP_AJ_G0026780	protein coding gene	Chr2:161478720-161509926 (+)
AKR/J	MGP_AKRJ_G0026751	protein coding gene	Chr2:166236894-166269910 (+)
BALB/cJ	MGP_BALBcJ_G0026789	protein coding gene	Chr2:161797492-161828997 (+)
C3H/HeJ	MGP_C3HHeJ_G0026531	protein coding gene	Chr2:166584774-166619835 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027237	protein coding gene	Chr2:173171113-173204963 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024607	protein coding gene	Chr2:154771234-154803419 (+)
CAST/EiJ	MGP_CASTEiJ_G0025992	protein coding gene	Chr2:166943078-166977359 (+)
CBA/J	MGP_CBAJ_G0026508	protein coding gene	Chr2:179428293-179470033 (+)
DBA/2J	MGP_DBA2J_G0026646	protein coding gene	Chr2:160647523-160679383 (+)
FVB/NJ	MGP_FVBNJ_G0026612	protein coding gene	Chr2:159016315-159047651 (+)
LP/J	MGP_LPJ_G0026749	protein coding gene	Chr2:168374002-168407171 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026634	protein coding gene	Chr2:183116983-183149779 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027293	protein coding gene	Chr2:166117589-166157648 (+)
PWK/PhJ	MGP_PWKPhJ_G0025726	protein coding gene	Chr2:160195249-160226701 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025529	protein coding gene	Chr2:164990361-165023258 (+)
WSB/EiJ	MGP_WSBEiJ_G0026062	protein coding gene	Chr2:166987479-167022496 (+)

Human Ortholog

L3MBTL1, L3MBTL histone methyl-lysine binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

L3MBTL1, L3MBTL histone methyl-lysine binding protein 1
Synonyms

dJ138B7.3, H-L(3)MBT, L3MBTL, ZC2HC3
Links

HGNC:15905

NCBI Gene ID: 26013

neXtProt AC: NX_Q9Y468

UniProt: Q9Y468
Chr Location

20q13.12; chr20:43489442-43550954 (+) GRCh38

MGI Vertebrate Homology

L3mbtl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: L3MBTL1
Gene Tree

L3mbtl1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available

Mice homozygous for a knock-out allele exhibit normal nervous system phenotype, hematopoietic system phenotype, immune system phenotype, cellular phenotype, and lifespan.

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

919
Tissues

143
cDNA Data

6
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase l3mbtl1

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All Sequences

88
RefSeq

42
UniProt

8
CCDS

CCDS38314.1

Ensembl

ENSMUSG00000035576 (Evidence)
NCBI Gene

241764

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035576	Ensembl Gene Model \| MGI Sequence Detail	31051	C57BL/6J	± kb
transcript	ENSMUST00000035751	Ensembl \| MGI Sequence Detail	2724	Not Applicable
polypeptide	ENSMUSP00000044038	Ensembl \| MGI Sequence Detail	826	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000009640 lethal(3)malignant brain tumor-like protein 1

(term hierarchy)
InterPro Domains

IPR047361 Lethal(3)malignant brain tumor-like protein 1, first MBT repeat

IPR047362 Lethal(3)malignant brain tumor-like protein 1, third MBT repeat

IPR004092 Mbt repeat

IPR050548 Polycomb group and chromatin remodeling factors

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR002515 Zinc finger, C2H2C-type

IPR036060 Zinc finger, C2H2C-type superfamily

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 1

Summaries

All 35

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:270691 Mao W, et al., Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1. Cell Rep. 2018 Jun 12;23(11):3209-3222

TSS for L3mbtl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21421	Chr2:162785404-162785436 (+)	28 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24