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Lrrc7 Gene Detail
Summary
  • Symbol
    Lrrc7
  • Name
    leucine rich repeat containing 7
  • Synonyms
    densin, mKIAA1365
Location &
Maps
more
  • Sequence Map
    Chr3:157772823-158268254 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, Syntenic
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9048 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676665
 protein coding gene Chr3:157772823-158268254 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028017
 protein coding gene Chr3:162246574-162731624 (-)
A/J MGP_AJ_G0027975
 protein coding gene Chr3:156331071-156818783 (-)
AKR/J MGP_AKRJ_G0027941
 protein coding gene Chr3:160480796-160956864 (-)
BALB/cJ MGP_BALBcJ_G0027987
 protein coding gene Chr3:156144197-156607013 (-)
C3H/HeJ MGP_C3HHeJ_G0027717
 protein coding gene Chr3:160880535-161376302 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028430
 protein coding gene Chr3:167558253-168057599 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025769
 protein coding gene Chr3:150940808-151386340 (-)
CAST/EiJ MGP_CASTEiJ_G0027170
 protein coding gene Chr3:161029633-161531781 (-)
CBA/J MGP_CBAJ_G0027692
 protein coding gene Chr3:173505983-174022726 (-)
DBA/2J MGP_DBA2J_G0027832
 protein coding gene Chr3:155379852-155845854 (-)
FVB/NJ MGP_FVBNJ_G0027799
 protein coding gene Chr3:152729083-153193929 (-)
LP/J MGP_LPJ_G0027943
 protein coding gene Chr3:163571919-164053962 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027832
 protein coding gene Chr3:182090764-182664472 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028489
 protein coding gene Chr3:160161906-160636845 (-)
PWK/PhJ MGP_PWKPhJ_G0026893
 protein coding gene Chr3:155308546-155775192 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026721
 protein coding gene Chr3:158373231-158876801 (-)
WSB/EiJ MGP_WSBEiJ_G0027250
 protein coding gene Chr3:161126316-161605086 (-)



Homology
more
  • Human Ortholog
    LRRC7, leucine rich repeat containing 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC7, leucine rich repeat containing 7
  • Synonyms
    DENSIN
  • Links
    NCBI Gene ID: 57554
    UniProt: Q96NW7

  • Chr Location
    1p31.1; chr1:69567922-70151945 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LRRC7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit limb grasping, reduced long term depression, increased anxiety, increased aggression towards other mice, impaired spatial memory, decreased prepulse inhibition, decreased nesting building behavior, and abnormal dendritic spines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    5
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242274 NCBI Gene Model | MGI Sequence Detail 495432 C57BL/6J ±  kb
    transcript NM_001370781 RefSeq | MGI Sequence Detail 22635 C57BL/6  
    polypeptide Q80TE7 UniProt | EBI | MGI Sequence Detail 1490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442224
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:353360 Cesari E, et al., Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Nucleic Acids Res. 2024 May 8;52(8):4167-4184
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory