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Mir125a Gene Detail
Summary
  • Symbol
    Mir125a
  • Name
    microRNA 125a
  • Synonyms
    Mirn125a, mmu-mir-125a
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676809
    NCBI Gene: 387235
  • Member of
    Mirc9 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:18051074-18051141 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 10.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676809
 miRNA gene Chr17:18051074-18051141 (+)
129S1/SvImJ MGP_129S1SvImJ_G0008307
 miRNA gene Chr17:15836901-15836968 (+)
A/J MGP_AJ_G0008294
 miRNA gene Chr17:15482405-15482472 (+)
AKR/J MGP_AKRJ_G0008277
 miRNA gene Chr17:15558037-15558104 (+)
BALB/cJ MGP_BALBcJ_G0008279
 miRNA gene Chr17:15427857-15427924 (+)
C3H/HeJ MGP_C3HHeJ_G0008221
 miRNA gene Chr17:15774511-15774578 (+)
C57BL/6NJ MGP_C57BL6NJ_G0008476
 miRNA gene Chr17:16624384-16624451 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007532
 miRNA gene Chr17:13331257-13331324 (+)
CAST/EiJ MGP_CASTEiJ_G0008089
 miRNA gene Chr17:15585624-15585691 (+)
CBA/J MGP_CBAJ_G0008190
 miRNA gene Chr17:17193265-17193332 (+)
DBA/2J MGP_DBA2J_G0008223
 miRNA gene Chr17:15196748-15196815 (+)
FVB/NJ MGP_FVBNJ_G0008247
 miRNA gene Chr17:15007352-15007419 (+)
LP/J MGP_LPJ_G0008306
 miRNA gene Chr17:15831092-15831159 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0008211
 miRNA gene Chr17:16776823-16776890 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0008466
 miRNA gene Chr17:15744688-15744755 (+)
PWK/PhJ MGP_PWKPhJ_G0008010
 miRNA gene Chr17:14828428-14828495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0007899
 miRNA gene Chr17:14831272-14831339 (+)
WSB/EiJ MGP_WSBEiJ_G0008169
 miRNA gene Chr17:16033668-16033735 (+)



Homology
more
  • Human Ortholog
    MIR125A, microRNA 125a
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR125A, microRNA 125a
  • Synonyms
    mir-125a, MIRN125A, miRNA125A
  • Links
    NCBI Gene ID: 406910

  • Chr Location
    chr19:51693254-51693339 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased regulatory T cell numbers and increased susceptibility to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    33
  • Literature Summary
    12
Sequences &
Gene Models
less
  • All Sequences
    23
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 387235 NCBI Gene Model | MGI Sequence Detail 68 C57BL/6J ±  kb
transcript NR_029539 RefSeq | MGI Sequence Detail 68 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 9
    Primer pair 5
    Other 4
Other Database
Links
less
miRBase MI0000151
References
more
  • Summaries
    All 49
    Developmental Gene Expression 12
    Gene Ontology 9
    Phenotypes 5
  • Earliest
    J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
  • Latest
    J:328529 Hwang SJ, et al., miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1. Cell Death Differ. 2022 Jun;29(6):1199-1210
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory