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Mir140 Gene Detail
Summary
  • Symbol
    Mir140
  • Name
    microRNA 140
  • Synonyms
    Mirn140, mmu-mir-140
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676825
    NCBI Gene: 387158
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:108277876-108277945 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 54.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676825
 miRNA gene Chr8:108277876-108277945 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009148
 miRNA gene Chr8:110022768-110022837 (+)
A/J MGP_AJ_G0009129
 miRNA gene Chr8:105586190-105586259 (+)
AKR/J MGP_AKRJ_G0009118
 miRNA gene Chr8:108664318-108664387 (+)
BALB/cJ MGP_BALBcJ_G0009114
 miRNA gene Chr8:105796503-105796572 (+)
C3H/HeJ MGP_C3HHeJ_G0009053
 miRNA gene Chr8:109396116-109396185 (+)
C57BL/6NJ MGP_C57BL6NJ_G0009355
 miRNA gene Chr8:114004784-114004853 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008219
 miRNA gene Chr8:98682444-98682513 (+)
CAST/EiJ MGP_CASTEiJ_G0008887
 miRNA gene Chr8:108939478-108939547 (+)
CBA/J MGP_CBAJ_G0009022
 miRNA gene Chr8:117706776-117706845 (+)
DBA/2J MGP_DBA2J_G0009052
 miRNA gene Chr8:104916115-104916184 (+)
FVB/NJ MGP_FVBNJ_G0009069
 miRNA gene Chr8:103860923-103860992 (+)
LP/J MGP_LPJ_G0009148
 miRNA gene Chr8:110210923-110210992 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009035
 miRNA gene Chr8:120845949-120846018 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0009324
 miRNA gene Chr8:108610356-108610425 (+)
PWK/PhJ MGP_PWKPhJ_G0008814
 miRNA gene Chr8:104344459-104344528 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008656
 miRNA gene Chr8:107334379-107334448 (+)
WSB/EiJ MGP_WSBEiJ_G0008981
 miRNA gene Chr8:109321842-109321911 (+)



Homology
more
  • Human Ortholog
    MIR140, microRNA 140
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR140, microRNA 140
  • Synonyms
    mir-140, MIRN140, miRNA140, SEDN
  • Links
    NCBI Gene ID: 406932

  • Chr Location
    chr16:69933081-69933180 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mir140 mouse models; 2 with human MIR140 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 5 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased stature, body weight, and long bone length, cranofacial defects, and osteoarthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    80
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387158 NCBI Gene Model | MGI Sequence Detail 70 C57BL/6J ±  kb
    transcript NR_029553 RefSeq | MGI Sequence Detail 70 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 12
      Primer pair 5
      Other 7
    Other Database
    Links
    less
    miRBase MI0000165
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
    • Latest
      J:341255 Shin J, et al., MicroRNA-140 is not involved in sepsis-induced muscle atrophy. Am J Physiol Cell Physiol. 2023 Aug 1;325(2):C509-C518
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory