Mir1a-1 MGI Mouse Gene Detail - MGI:2676869

Symbol

Mir1a-1
Name

microRNA 1a-1
Synonyms

Mirn1-1, Mirn1b, Mirn1c, Mirn1d, mmu-mir-1-1, mmu-mir-1a-1

Feature Type

miRNA gene
IDs

MGI:2676869
NCBI Gene: 387136
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:180030841-180030917 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 102.92 cM
Mapping Data

1 experiment

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676869	miRNA gene	Chr2:180030841-180030917 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008622	miRNA gene	Chr2:186904778-186904854 (+)
A/J	MGP_AJ_G0008612	miRNA gene	Chr2:179229668-179229744 (+)
AKR/J	MGP_AKRJ_G0008601	miRNA gene	Chr2:184604087-184604163 (+)
BALB/cJ	MGP_BALBcJ_G0008599	miRNA gene	Chr2:179693626-179693702 (+)
C3H/HeJ	MGP_C3HHeJ_G0008541	miRNA gene	Chr2:184941806-184941882 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008811	miRNA gene	Chr2:192297576-192297652 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007786	miRNA gene	Chr2:169921520-169921596 (+)
CAST/EiJ	MGP_CASTEiJ_G0008396	miRNA gene	Chr2:183192367-183192443 (+)
CBA/J	MGP_CBAJ_G0008505	miRNA gene	Chr2:199300877-199300953 (+)
DBA/2J	MGP_DBA2J_G0008539	miRNA gene	Chr2:178328212-178328288 (+)
FVB/NJ	MGP_FVBNJ_G0008560	miRNA gene	Chr2:176936153-176936229 (+)
LP/J	MGP_LPJ_G0008629	miRNA gene	Chr2:186911073-186911149 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008523	miRNA gene	Chr2:201907002-201907078 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008794	miRNA gene	Chr2:184557540-184557616 (+)
PWK/PhJ	MGP_PWKPhJ_G0008321	miRNA gene	Chr2:175837966-175838042 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0008177	miRNA gene	Chr2:181053582-181053658 (+)
WSB/EiJ	MGP_WSBEiJ_G0008480	miRNA gene	Chr2:185538923-185538999 (+)

Human Ortholog

MIR1-1, microRNA 1-1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR1-1, microRNA 1-1
Synonyms

hsa-mir-1-1, mir-1-1, MIRN1-1, miRNA1-1
Links

HGNC:31499

NCBI Gene ID: 406904
Chr Location

chr20:62554306-62554376 (+) GRCh38

MGI Vertebrate Homology

Mir1a-1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR1-1
Gene Tree

Mir1a-1

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
18 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Mir1a-1
Find Mice (IMSR)

0 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial lethality before weaning and subtle cardiac defects, including intermittent atrial arrhythmias, mild ventricular dilation, and conduction abnormalities. Lethality is strain-dependent.

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All GO Annotations

8
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

28
Literature Summary

35

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

26
RefSeq

1

Ensembl

ENSMUSG00000070144 (Evidence)
NCBI Gene

387136

Representative Sequences				Length	Strain/Species	Flank
	genomic	387136	NCBI Gene Model \| MGI Sequence Detail	77	C57BL/6J	± kb
	transcript	NR_029528	RefSeq \| MGI Sequence Detail	77	C57BL/6

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All nucleic 8

Primer pair 2

Other 6

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miRBase

MI0000139

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MGI:2676870, MGI:2676871

Summaries

All 70

Developmental Gene Expression 35

Gene Ontology 7

Phenotypes 9
Earliest

J:14774 Jakoby WB, et al., Glutathione transferases: nomenclature. Biochem Pharmacol. 1984 Aug 15;33(16):2539-40
Latest

J:357928 Piasecka A, et al., MBNL splicing factors regulate the microtranscriptome of skeletal muscles. Nucleic Acids Res. 2024 Oct 28;52(19):12055-12073

TSS for Mir1a-1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22222	Chr2:180029855-180029858 (+)	-984 bp
Tssr22223	Chr2:180030912-180030915 (+)	73 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24