Mir203 MGI Mouse Gene Detail - MGI:2676878

Symbol

Mir203
Name

microRNA 203
Synonyms

Mirn203, mmu-mir-203

Feature Type

miRNA gene
IDs

MGI:2676878
NCBI Gene: 387199
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:112097314-112097389 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.14 cM
Mapping Data

1 experiment

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676878	miRNA gene	Chr12:112097314-112097389 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008027	miRNA gene	Chr12:114564347-114564422 (+)
A/J	MGP_AJ_G0008021	miRNA gene	Chr12:110152017-110152092 (+)
AKR/J	MGP_AKRJ_G0007998	miRNA gene	Chr12:113328648-113328723 (+)
BALB/cJ	MGP_BALBcJ_G0008000	miRNA gene	Chr12:110581709-110581784 (+)
C3H/HeJ	MGP_C3HHeJ_G0007946	miRNA gene	Chr12:113820812-113820887 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008181	miRNA gene	Chr12:118118347-118118422 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007308	miRNA gene	Chr12:106590893-106590968 (+)
CAST/EiJ	MGP_CASTEiJ_G0007834	miRNA gene	Chr12:108674090-108674165 (+)
CBA/J	MGP_CBAJ_G0007916	miRNA gene	Chr12:122633167-122633242 (+)
DBA/2J	MGP_DBA2J_G0007951	miRNA gene	Chr12:109636920-109636995 (+)
FVB/NJ	MGP_FVBNJ_G0007970	miRNA gene	Chr12:108442258-108442333 (+)
LP/J	MGP_LPJ_G0008032	miRNA gene	Chr12:114388152-114388227 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007941	miRNA gene	Chr12:125735173-125735248 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008176	miRNA gene	Chr12:112843054-112843129 (+)
PWK/PhJ	MGP_PWKPhJ_G0007756	miRNA gene	Chr12:104279288-104279363 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007653	miRNA gene	Chr12:107001433-107001508 (+)
WSB/EiJ	MGP_WSBEiJ_G0007903	miRNA gene	Chr12:113740684-113740759 (+)

Human Ortholog

MIR203A, microRNA 203a

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR203A, microRNA 203a
Synonyms

hsa-mir-203a, miR-203, MIR203, mir-203a, MIRN203, miRNA203
Links

HGNC:31581

NCBI Gene ID: 406986
Chr Location

chr14:104117405-104117514 (+) GRCh38

Human Ortholog

MIR203B, microRNA 203b
Synonyms

hsa-mir-203b, MIR3545
Links

HGNC:41811

NCBI Gene ID: 100616173
Chr Location

chr14:104117418-104117503 (-) GRCh38

MGI Vertebrate Homology

Mir203 stringent orthology
2 human;1 mouse
HCOP

vertebrate homology predictions: MIR203A, MIR203B
Gene Tree

Mir203

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Find Mice (IMSR)

4 strains or lines available

Mice homozygous for a knock-out allele exhibit mild epidermal hyperplasia during skin development, decreased tumor latency, and increased incidence of tumors by chemical induction.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

21
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

25
RefSeq

1

Ensembl

ENSMUSG00000065574 (Evidence)
NCBI Gene

387199

Representative Sequences				Length	Strain/Species	Flank
	genomic	387199	NCBI Gene Model \| MGI Sequence Detail	76	C57BL/6J	± kb
	transcript	NR_029590	RefSeq \| MGI Sequence Detail	76	C57BL/6

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All nucleic 4

Other 4

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miRBase

MI0000246

Summaries

All 37

Developmental Gene Expression 14

Gene Ontology 3

Phenotypes 4
Earliest

J:84908 Lagos-Quintana M, et al., New microRNAs from mouse and human. RNA. 2003 Feb;9(2):175-9
Latest

J:331421 Funato N, et al., TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties. Sci Rep. 2022 Nov 23;12(1):20188

TSS for Mir203:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115368	Chr12:112097213-112097219 (+)	-98 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24