Mir217 MGI Mouse Gene Detail - MGI:2676893

Symbol

Mir217
Name

microRNA 217
Synonyms

Mirn217, mmu-mir-217

Feature Type

miRNA gene
IDs

MGI:2676893
NCBI Gene: 387213
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:28713728-28713835 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 16.23 cM
Mapping Data

1 experiment

SNPs within 2kb

103 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676893	miRNA gene	Chr11:28713728-28713835 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0007791	miRNA gene	Chr11:26749207-26749314 (+)
A/J	MGP_AJ_G0007787	miRNA gene	Chr11:25781906-25782013 (+)
AKR/J	MGP_AKRJ_G0007761	miRNA gene	Chr11:26601534-26601641 (+)
BALB/cJ	MGP_BALBcJ_G0007764	miRNA gene	Chr11:25938797-25938904 (+)
C3H/HeJ	MGP_C3HHeJ_G0007711	miRNA gene	Chr11:26542101-26542208 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0007942	miRNA gene	Chr11:27732260-27732367 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007090	miRNA gene	Chr11:24453141-24453248 (+)
CAST/EiJ	MGP_CASTEiJ_G0007606	miRNA gene	Chr11:26585063-26585170 (+)
CBA/J	MGP_CBAJ_G0007683	miRNA gene	Chr11:28998574-28998681 (+)
DBA/2J	MGP_DBA2J_G0007718	miRNA gene	Chr11:25630058-25630165 (+)
FVB/NJ	MGP_FVBNJ_G0007735	miRNA gene	Chr11:25435557-25435664 (+)
LP/J	MGP_LPJ_G0007795	miRNA gene	Chr11:27010485-27010592 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007706	miRNA gene	Chr11:30015339-30015446 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0007940	miRNA gene	Chr11:26741164-26741271 (+)
PWK/PhJ	MGP_PWKPhJ_G0007535	miRNA gene	Chr11:25735468-25735575 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007432	miRNA gene	Chr11:26424284-26424391 (+)
WSB/EiJ	MGP_WSBEiJ_G0007672	miRNA gene	Chr11:26416205-26416312 (+)

Human Ortholog

MIR217, microRNA 217

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR217, microRNA 217
Synonyms

mir-217, MIRN217
Links

HGNC:31594

NCBI Gene ID: 406999
Chr Location

chr2:55982967-55983076 (-) GRCh38

MGI Vertebrate Homology

Mir217 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR217
Gene Tree

Mir217

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Phenotype Summary

3 phenotypes from multigenic genotypes
4 phenotype references

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Mir217
Find Mice (IMSR)

0 strains or lines available

Mice homozygous for a null allele exhibit pancreatic acinar-to-ductal metaplasia in vitro and increased susceptibility to induced pancreatitis.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

25
RefSeq

1

Ensembl

ENSMUSG00000065415 (Evidence)
NCBI Gene

387213

Representative Sequences				Length	Strain/Species	Flank
	genomic	387213	NCBI Gene Model \| MGI Sequence Detail	108	C57BL/6J	± kb
	transcript	NR_029828	RefSeq \| MGI Sequence Detail	108	C57BL/6

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All nucleic 2

Other 2

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miRBase

MI0000731

Summaries

All 22

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 4
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:297754 de Yebenes VG, et al., Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction. Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2408-2424

TSS for Mir217:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100685	Chr11:28713468-28713472 (+)	-258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24