Ostn MGI Mouse Gene Detail - MGI:2677164

Symbol

Ostn
Name

osteocrin
Synonyms

musclin, Ostc

Feature Type

protein coding gene
IDs

MGI:2677164
NCBI Gene: 239790
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:27126239-27169962 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 18.88 cM
Mapping Data

1 experiment

SNPs within 2kb

1741 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2677164	protein coding gene	Chr16:27125733-27169962 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022698	protein coding gene	Chr16:25075349-25118480 (+)
A/J	MGP_AJ_G0022660	protein coding gene	Chr16:23891277-23934727 (+)
AKR/J	MGP_AKRJ_G0022634	protein coding gene	Chr16:24855686-24898081 (+)
BALB/cJ	MGP_BALBcJ_G0022665	protein coding gene	Chr16:24089604-24135702 (+)
C3H/HeJ	MGP_C3HHeJ_G0022429	protein coding gene	Chr16:24956857-25011976 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023114	protein coding gene	Chr16:25592541-25651654 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020632	protein coding gene	Chr16:24436613-24481641 (+)
CAST/EiJ	MGP_CASTEiJ_G0021958	protein coding gene	Chr16:24998547-25043809 (+)
CBA/J	MGP_CBAJ_G0022400	protein coding gene	Chr16:26722259-26772508 (+)
DBA/2J	MGP_DBA2J_G0022532	protein coding gene	Chr16:23836116-23878043 (+)
FVB/NJ	MGP_FVBNJ_G0022508	protein coding gene	Chr16:23809990-23858652 (+)
LP/J	MGP_LPJ_G0022600	protein coding gene	Chr16:24849894-24896634 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022527	protein coding gene	Chr16:26182094-26251939 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023126	protein coding gene	Chr16:24814161-24859014 (+)
PWK/PhJ	MGP_PWKPhJ_G0021697	protein coding gene	Chr16:24106028-24145681 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021528	protein coding gene	Chr16:24543717-24586064 (+)
WSB/EiJ	MGP_WSBEiJ_G0022002	protein coding gene	Chr16:24751879-24794013 (+)

Human Ortholog

OSTN, osteocrin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OSTN, osteocrin
Synonyms

MUSCLIN
Links

HGNC:29961

NCBI Gene ID: 344901

neXtProt AC: NX_P61366

UniProt: P61366
Chr Location

3q28; chr3:191199241-191265615 (+) GRCh38

MGI Vertebrate Homology

Ostn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OSTN
Gene Tree

Ostn

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a null allele display impaired exercise endurance and impaired muscle adaptation to exercise.

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

24
cDNA Data

7
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ostn

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS28090.1

Ensembl

ENSMUSG00000052276 (Evidence)
NCBI Gene

239790

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052276	Ensembl Gene Model \| MGI Sequence Detail	43724	C57BL/6J	± kb
transcript	ENSMUST00000066852	Ensembl \| MGI Sequence Detail	1423	Not Applicable
polypeptide	ENSMUSP00000067539	Ensembl \| MGI Sequence Detail	130	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012069 osteocrin

(term hierarchy)
InterPro Domains

IPR021088 Osteocrin

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 1

Summaries

All 38

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 12
Earliest

J:87170 Thomas G, et al., Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. J Biol Chem. 2003 Dec 12;278(50):50563-71
Latest

J:358302 Kang X, et al., Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis. Cell Stem Cell. 2024 Feb 1;31(2):212-226.e7

TSS for Ostn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137819	Chr16:27126382-27126400 (+)	152 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24