Rnf149 MGI Mouse Gene Detail - MGI:2677438

Symbol

Rnf149
Name

ring finger protein 149
Synonyms

1600023E10Rik, Greul4

Feature Type

protein coding gene
IDs

MGI:2677438
NCBI Gene: 67702
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr1:39590377-39616486 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 18.33 cM
Mapping Data

2 experiments

SNPs within 2kb

616 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2677438	protein coding gene	Chr1:39590375-39616885 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015959	protein coding gene	Chr1:38297912-38323905 (-)
A/J	MGP_AJ_G0015943	protein coding gene	Chr1:37227122-37253179 (-)
AKR/J	MGP_AKRJ_G0015898	protein coding gene	Chr1:37729914-37755905 (-)
BALB/cJ	MGP_BALBcJ_G0015897	protein coding gene	Chr1:36875172-36901583 (-)
C3H/HeJ	MGP_C3HHeJ_G0015730	protein coding gene	Chr1:37991831-38017830 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016350	protein coding gene	Chr1:39894804-39921804 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014072	protein coding gene	Chr1:34191062-34216537 (-)
CAST/EiJ	MGP_CASTEiJ_G0015311	protein coding gene	Chr1:37870447-37897286 (-)
CBA/J	MGP_CBAJ_G0015702	protein coding gene	Chr1:41047769-41075829 (-)
DBA/2J	MGP_DBA2J_G0015803	protein coding gene	Chr1:36511659-36537685 (-)
FVB/NJ	MGP_FVBNJ_G0015805	protein coding gene	Chr1:36046350-36072516 (-)
LP/J	MGP_LPJ_G0015873	protein coding gene	Chr1:38636299-38663208 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015825	protein coding gene	Chr1:43096035-43122244 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016397	protein coding gene	Chr1:37849577-37876962 (-)
PWK/PhJ	MGP_PWKPhJ_G0015094	protein coding gene	Chr1:36327632-36353917 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014876	protein coding gene	Chr1:37785135-37812678 (-)
WSB/EiJ	MGP_WSBEiJ_G0015373	protein coding gene	Chr1:37804220-37830218 (-)

Human Ortholog

RNF149, ring finger protein 149

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF149, ring finger protein 149
Synonyms

DNAPTP2
Links

HGNC:23137

NCBI Gene ID: 284996

neXtProt AC: NX_Q8NC42

UniProt: Q8NC42
Chr Location

2q11.2; chr2:101271219-101308701 (-) GRCh38

MGI Vertebrate Homology

Rnf149 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNF149
Gene Tree

Rnf149

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Rnf149
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a null mutation display hyperproliferation of several hematological cell lineages.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

128
cDNA Data

122
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RNF149

Xenbase rnf149

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All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS14907.1

Ensembl

ENSMUSG00000048234 (Evidence)
NCBI Gene

67702

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048234	Ensembl Gene Model \| MGI Sequence Detail	26110	C57BL/6J	± kb
transcript	ENSMUST00000062525	Ensembl \| MGI Sequence Detail	2492	Not Applicable
polypeptide	ENSMUSP00000050388	Ensembl \| MGI Sequence Detail	394	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014092 E3 ubiquitin-protein ligase RNF149

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR042712 E3 ubiquitin-protein ligase RNF149, RING finger, H2 subclass

IPR003137 PA domain

IPR046450 PA domain superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q3U2C5 3 sites

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All nucleic 124

cDNA 123

Other 1

Microarray probesets 3

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MGI:1914952, MGI:2138516, MGI:2138655

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:335358 Legesse A, et al., The role of RNF149 in the pre-emptive quality control substrate ubiquitination. Commun Biol. 2023 Apr 8;6(1):385

TSS for Rnf149:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11400	Chr1:39616421-39616508 (-)	21 bp
Tssr11399	Chr1:39616398-39616412 (-)	81 bp
Tssr11398	Chr1:39616369-39616393 (-)	105 bp
Tssr11397	Chr1:39610238-39610245 (-)	6,244 bp
Tssr11396	Chr1:39610081-39610108 (-)	6,391 bp
Tssr11395	Chr1:39610005-39610055 (-)	6,456 bp
Tssr11394	Chr1:39606698-39606704 (-)	9,785 bp
Tssr11393	Chr1:39606095-39606129 (-)	10,374 bp
Tssr11392	Chr1:39603124-39603132 (-)	13,358 bp
Tssr11391	Chr1:39598042-39598054 (-)	18,438 bp
Tssr11390	Chr1:39598012-39598024 (-)	18,468 bp
Tssr11389	Chr1:39597443-39597461 (-)	19,034 bp
Tssr11388	Chr1:39597382-39597406 (-)	19,092 bp
Tssr11387	Chr1:39596900-39596910 (-)	19,581 bp
Tssr11386	Chr1:39595078-39595103 (-)	21,395 bp
Tssr11385	Chr1:39594721-39594754 (-)	21,748 bp
Tssr11384	Chr1:39594604-39594624 (-)	21,872 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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