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Zc4h2 Gene Detail
Summary
  • Symbol
    Zc4h2
  • Name
    zinc finger, C4H2 domain containing
  • Synonyms
    LOC245522, mKIAA1166
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679294
    NCBI Gene: 245522
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:94682799-94702115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    408 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679294
 protein coding gene ChrX:94682793-94702115 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035919
 protein coding gene ChrX:91977988-91996797 (-)
A/J MGP_AJ_G0035905
 protein coding gene ChrX:92200437-92222308 (-)
AKR/J MGP_AKRJ_G0035821
 protein coding gene ChrX:94622458-94644265 (-)
BALB/cJ MGP_BALBcJ_G0035889
 protein coding gene ChrX:90932351-90956535 (-)
C3H/HeJ MGP_C3HHeJ_G0035597
 protein coding gene ChrX:92506922-92526871 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036418
 protein coding gene ChrX:94909365-94932945 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033246
 protein coding gene ChrX:90241164-90258684 (-)
CAST/EiJ MGP_CASTEiJ_G0034883
 protein coding gene ChrX:77013895-77038327 (-)
CBA/J MGP_CBAJ_G0035572
 protein coding gene ChrX:97708903-97732627 (-)
DBA/2J MGP_DBA2J_G0035727
 protein coding gene ChrX:91360383-91388647 (-)
FVB/NJ MGP_FVBNJ_G0035665
 protein coding gene ChrX:90792296-90809919 (-)
LP/J MGP_LPJ_G0035817
 protein coding gene ChrX:92984000-93004027 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035700
 protein coding gene ChrX:102035398-102061370 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036445
 protein coding gene ChrX:91727274-91747278 (-)
PWK/PhJ MGP_PWKPhJ_G0034583
 protein coding gene ChrX:74681601-74702944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034412
 protein coding gene ChrX:77791961-77811984 (-)
WSB/EiJ MGP_WSBEiJ_G0035023
 protein coding gene ChrX:90583094-90603479 (-)



Homology
more
  • Human Ortholog
    ZC4H2, zinc finger C4H2-type containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZC4H2, zinc finger C4H2-type containing
  • Synonyms
    HCA127, KIAA1166, MCS, MRXS4, WRWF, WRWFFR, WWS
  • Links
    NCBI Gene ID: 55906
    neXtProt AC: NX_Q9NQZ6
    UniProt: Q9NQZ6

  • Chr Location
    Xq11.2; chrX:64915802-65034741 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ZC4H2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for a knock-out allele exhibit neonatal lethality and ventral spinal cord patterning defects. About 50% of heterozygous females display postnatal growth retardation and fail to survive to adulthood, with some embryos exhibiting similar spinal cord patterning defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    18
  • cDNA Data
    32
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035062 Ensembl Gene Model | MGI Sequence Detail 19317 C57BL/6J ±  kb
    transcript ENSMUST00000044382 Ensembl | MGI Sequence Detail 2219 Not Applicable  
    polypeptide ENSMUSP00000041236 Ensembl | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685218
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 4
    • Earliest
      J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
    • Latest
      J:291948 Ma P, et al., ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. J Mol Cell Biol. 2020 Jun 11;12(5):337-344
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory