Pak6 MGI Mouse Gene Detail - MGI:2679420 - p21 (RAC1) activated kinase 6

Symbol

Pak6
Name

p21 (RAC1) activated kinase 6

Feature Type

protein coding gene
IDs

MGI:2679420
NCBI Gene: 214230
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:118493784-118528501 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.41 cM
Mapping Data

1 experiment

SNPs within 2kb

814 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679420	protein coding gene	Chr2:118493531-118528501 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026318	protein coding gene	Chr2:121355934-121395408 (+)
A/J	MGP_AJ_G0026279	protein coding gene	Chr2:116437417-116473524 (+)
AKR/J	MGP_AKRJ_G0026258	protein coding gene	Chr2:119701544-119736480 (+)
BALB/cJ	MGP_BALBcJ_G0026292	protein coding gene	Chr2:116692814-116727936 (+)
C3H/HeJ	MGP_C3HHeJ_G0026038	protein coding gene	Chr2:120162184-120198006 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026739	protein coding gene	Chr2:125368524-125403168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024119	protein coding gene	Chr2:111482761-111517362 (+)
CAST/EiJ	MGP_CASTEiJ_G0025500	protein coding gene	Chr2:120471117-120507195 (+)
CBA/J	MGP_CBAJ_G0026014	protein coding gene	Chr2:129791117-129825686 (+)
DBA/2J	MGP_DBA2J_G0026153	protein coding gene	Chr2:115856120-115891291 (+)
FVB/NJ	MGP_FVBNJ_G0026115	protein coding gene	Chr2:114685423-114720343 (+)
LP/J	MGP_LPJ_G0026254	protein coding gene	Chr2:121690972-121726618 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026134	protein coding gene	Chr2:134160868-134196826 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026794	protein coding gene	Chr2:119824505-119859121 (+)
PWK/PhJ	MGP_PWKPhJ_G0025236	protein coding gene	Chr2:115410583-115445776 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025035	protein coding gene	Chr2:118990195-119025798 (+)
WSB/EiJ	MGP_WSBEiJ_G0025569	protein coding gene	Chr2:120639960-120674572 (+)

Human Ortholog

BUB1B-PAK6, BUB1B-PAK6 readthrough

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BUB1B-PAK6, BUB1B-PAK6 readthrough
Synonyms

PAK-5, PAK5, PAK-6, PAK6
Links

HGNC:52276

NCBI Gene ID: 106821730

neXtProt AC: NX_Q9NQU5
Chr Location

15q15.1; chr15:40217428-40277487 (+) GRCh38

Human Ortholog

PAK6, p21 (RAC1) activated kinase 6
Synonyms

PAK5
Links

HGNC:16061

NCBI Gene ID: 56924

neXtProt AC: NX_Q9NQU5

UniProt: Q9NQU5
Chr Location

15q15.1; chr15:40217428-40277487 (+) GRCh38

MGI Vertebrate Homology

Pak6 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BUB1B-PAK6, PAK6
Gene Tree

Pak6

Diseases

1 with human PAK6 associations

				Human Disease	Mouse Models
				clear cell renal cell carcinoma IDs clear cell renal cell carcinoma DOID:4467 MESH:D002292 NCI:C4033 UMLS_CUI:C0279702

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Pak6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Mice homozygous for a null allele do not exhibit any abnormal phenotype.

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All GO Annotations

41
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

37
cDNA Data

20
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pak6

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All Sequences

50
RefSeq

11
UniProt

2
CCDS

CCDS16580.1

Ensembl

ENSMUSG00000074923 (Evidence)
NCBI Gene

214230

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074923	Ensembl Gene Model \| MGI Sequence Detail	34718	C57BL/6J	± kb
transcript	ENSMUST00000099557	Ensembl \| MGI Sequence Detail	4411	Not Applicable
polypeptide	ENSMUSP00000097153	Ensembl \| MGI Sequence Detail	682	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012244 serine/threonine-protein kinase PAK 6

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000095 CRIB domain

IPR036936 CRIB domain superfamily

IPR033923 p21 activated kinase binding domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR035066 Serine/threonine-protein kinase PAK 6, catalytic domain

IPR050285 STE20 Serine/Threonine-Protein Kinase

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All nucleic 21

cDNA 21

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:357470 Hu B, et al., PAK2 is necessary for myelination in the peripheral nervous system. Brain. 2024 May 3;147(5):1809-1821

TSS for Pak6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19565	Chr2:118493716-118493790 (+)	-31 bp
Tssr19566	Chr2:118493792-118493809 (+)	17 bp
Tssr19567	Chr2:118494203-118494243 (+)	439 bp
Tssr613	Chr2:118507709-118507764 (+)	13,953 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24