Slitrk5 MGI Mouse Gene Detail - MGI:2679448 - SLIT and NTRK-like family, member 5

Symbol

Slitrk5
Name

SLIT and NTRK-like family, member 5
Synonyms

2610019D03Rik

Feature Type

protein coding gene
IDs

MGI:2679448
NCBI Gene: 75409
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:111912547-111920576 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 57.86 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

236 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679448	protein coding gene	Chr14:111912529-111920576 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021643	protein coding gene	Chr14:108943273-108952048 (+)
A/J	MGP_AJ_G0021602	protein coding gene	Chr14:104905872-104914996 (+)
AKR/J	MGP_AKRJ_G0021578	protein coding gene	Chr14:108310638-108318677 (+)
BALB/cJ	MGP_BALBcJ_G0021608	protein coding gene	Chr14:105379602-105387660 (+)
C3H/HeJ	MGP_C3HHeJ_G0021386	protein coding gene	Chr14:108106508-108115251 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022047	protein coding gene	Chr14:113135615-113144893 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019587	protein coding gene	Chr14:101267807-101275719 (+)
CAST/EiJ	MGP_CASTEiJ_G0020902	protein coding gene	Chr14:105900894-105910336 (+)
CBA/J	MGP_CBAJ_G0021354	protein coding gene	Chr14:117500779-117508789 (+)
DBA/2J	MGP_DBA2J_G0021477	protein coding gene	Chr14:104805983-104814740 (+)
FVB/NJ	MGP_FVBNJ_G0021455	protein coding gene	Chr14:103245320-103253520 (+)
LP/J	MGP_LPJ_G0021545	protein coding gene	Chr14:109985585-109993583 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021481	protein coding gene	Chr14:121723402-121732005 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022071	protein coding gene	Chr14:107676266-107684264 (+)
PWK/PhJ	MGP_PWKPhJ_G0020646	protein coding gene	Chr14:101772235-101780248 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020484	protein coding gene	Chr14:103975523-103983565 (+)
WSB/EiJ	MGP_WSBEiJ_G0020956	protein coding gene	Chr14:108476508-108486277 (+)

Human Ortholog

SLITRK5, SLIT and NTRK like family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLITRK5, SLIT and NTRK like family member 5
Synonyms

bA364G4.2, LRRC11
Links

HGNC:20295

NCBI Gene ID: 26050

neXtProt AC: NX_O94991

UniProt: O94991
Chr Location

13q31.2; chr13:87671371-87696272 (+) GRCh38

MGI Vertebrate Homology

Slitrk5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLITRK5
Gene Tree

Slitrk5

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Slitrk5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have abnormal medium spiny neuron morphology and exhibit behavioral abnormalities.

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All GO Annotations

22
GO References

8

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

76
cDNA Data

8
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slitrk5

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All Sequences

45
RefSeq

8
UniProt

3
CCDS

CCDS27328.1

Ensembl

ENSMUSG00000033214 (Evidence)
NCBI Gene

75409

			Length	Strain/Species	Flank
genomic	75409	NCBI Gene Model \| MGI Sequence Detail	8030	C57BL/6J	± kb
transcript	NM_001378770	RefSeq \| MGI Sequence Detail	5242	C57BL/6
polypeptide	Q810B7	UniProt \| EBI \| MGI Sequence Detail	957	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015241 SLIT and NTRK-like protein 5

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR043326 Slitrk family
GlyGen

Q810B7 4 sites, 1 O-linked glycan (2 sites)

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All nucleic 11

cDNA 9

Other 2

Microarray probesets 3

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MGI:1922659

Summaries

All 47

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348363 Matsumoto Y, et al., Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala. Front Mol Neurosci. 2024;17:1386924

TSS for Slitrk5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127112	Chr14:111912292-111912356 (+)	-223 bp
Tssr127113	Chr14:111912545-111912551 (+)	1 bp
Tssr127114	Chr14:111912951-111912964 (+)	411 bp
Tssr127115	Chr14:111913440-111913471 (+)	909 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24