Slitrk2 MGI Mouse Gene Detail - MGI:2679449 - SLIT and NTRK-like family, member 2

Symbol

Slitrk2
Name

SLIT and NTRK-like family, member 2

Feature Type

protein coding gene
IDs

MGI:2679449
NCBI Gene: 245450
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:65692924-65704999 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 34.81 cM, cytoband A5
Mapping Data

1 experiment

SNPs within 2kb

167 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679449	protein coding gene	ChrX:65692535-65705008 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035769	protein coding gene	ChrX:62220429-62232508 (+)
A/J	MGP_AJ_G0035751	protein coding gene	ChrX:62379326-62392039 (+)
AKR/J	MGP_AKRJ_G0035671	protein coding gene	ChrX:64117828-64131029 (+)
BALB/cJ	MGP_BALBcJ_G0035738	protein coding gene	ChrX:61685754-61701484 (+)
C3H/HeJ	MGP_C3HHeJ_G0035441	protein coding gene	ChrX:62722970-62735003 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036270	protein coding gene	ChrX:64061982-64075191 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033119	protein coding gene	ChrX:61692606-61704657 (+)
CAST/EiJ	MGP_CASTEiJ_G0034733	protein coding gene	ChrX:48278373-48290491 (+)
CBA/J	MGP_CBAJ_G0035415	protein coding gene	ChrX:65874774-65887046 (+)
DBA/2J	MGP_DBA2J_G0035569	protein coding gene	ChrX:61936002-61947715 (+)
FVB/NJ	MGP_FVBNJ_G0035519	protein coding gene	ChrX:61443844-61455833 (+)
LP/J	MGP_LPJ_G0035657	protein coding gene	ChrX:63006957-63019023 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035555	protein coding gene	ChrX:67940754-67949511 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036289	protein coding gene	ChrX:62102136-62114191 (+)
PWK/PhJ	MGP_PWKPhJ_G0034431	protein coding gene	ChrX:46506353-46526994 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034272	protein coding gene	ChrX:49236864-49249877 (+)
WSB/EiJ	MGP_WSBEiJ_G0034876	protein coding gene	ChrX:61520659-61532730 (+)

Human Ortholog

SLITRK2, SLIT and NTRK like family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLITRK2, SLIT and NTRK like family member 2
Synonyms

CXorf1, CXorf2, SLITL1, TMEM257, XLID111
Links

HGNC:13449

NCBI Gene ID: 84631

neXtProt AC: NX_Q9H156

UniProt: Q9H156
Chr Location

Xq27.3; chrX:145817829-145829856 (+) GRCh38

MGI Vertebrate Homology

Slitrk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLITRK2
Gene Tree

Slitrk2

Diseases

1 with Slitrk2 mouse models; 1 with human SLITRK2 associations

Human Disease

Mouse Models

non-syndromic X-linked intellectual developmental disorder 111

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

31 phenotypes from 3 alleles in 4 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Spontaneous

1
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit hyperactivity, decreased exploration, increased coping response, increased vestibuloocular reflex, and disrupted serotonin metabolism.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

922
Tissues

112
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slitrk2

ZFIN slitrk2

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All Sequences

49
RefSeq

12
UniProt

3
CCDS

CCDS30169.1

Ensembl

ENSMUSG00000036790 (Evidence)
NCBI Gene

245450

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036790	Ensembl Gene Model \| MGI Sequence Detail	12076	C57BL/6J	± kb
transcript	ENSMUST00000036043	Ensembl \| MGI Sequence Detail	2992	Not Applicable
polypeptide	ENSMUSP00000044094	Ensembl \| MGI Sequence Detail	846	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015238 SLIT and NTRK-like protein 2

(term hierarchy)
PDB

4Y61
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

IPR043326 Slitrk family
GlyGen

Q810C0 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 11

Other 2

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 8

Diseases 1

Gene Ontology 8

Phenotypes 7
Earliest

J:85959 Aruga J, et al., Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. Mol Cell Neurosci. 2003 Sep;24(1):117-29
Latest

J:348363 Matsumoto Y, et al., Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala. Front Mol Neurosci. 2024;17:1386924

TSS for Slitrk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161127	ChrX:65692982-65693000 (+)	67 bp
Tssr161128	ChrX:65693042-65693053 (+)	124 bp
Tssr161129	ChrX:65696609-65696637 (+)	3,699 bp
Tssr161130	ChrX:65696643-65696651 (+)	3,723 bp
Tssr161131	ChrX:65700517-65700522 (+)	7,596 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24