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Paqr3 Gene Detail
Summary
  • Symbol
    Paqr3
  • Name
    progestin and adipoQ receptor family member III
  • Synonyms
    6330415A20Rik, RKTG
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679683
    NCBI Gene: 231474
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:97230188-97259455 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    977 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679683
 protein coding gene Chr5:97229223-97259608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029768
 protein coding gene Chr5:98359744-98389988 (-)
A/J MGP_AJ_G0029734
 protein coding gene Chr5:94733948-94763245 (-)
AKR/J MGP_AKRJ_G0029680
 protein coding gene Chr5:97897961-97927637 (-)
BALB/cJ MGP_BALBcJ_G0029744
 protein coding gene Chr5:95740912-95770157 (-)
C3H/HeJ MGP_C3HHeJ_G0029467
 protein coding gene Chr5:98230138-98260149 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030199
 protein coding gene Chr5:102537912-102569356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027434
 protein coding gene Chr5:90107266-90136509 (-)
CAST/EiJ MGP_CASTEiJ_G0028877
 protein coding gene Chr5:96831541-96861994 (-)
CBA/J MGP_CBAJ_G0029437
 protein coding gene Chr5:106061683-106092758 (-)
DBA/2J MGP_DBA2J_G0029581
 protein coding gene Chr5:94942597-94972134 (-)
FVB/NJ MGP_FVBNJ_G0029540
 protein coding gene Chr5:93768703-93799514 (-)
LP/J MGP_LPJ_G0029669
 protein coding gene Chr5:99013751-99043927 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029569
 protein coding gene Chr5:111135883-111167363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030232
 protein coding gene Chr5:97339383-97369598 (-)
PWK/PhJ MGP_PWKPhJ_G0028596
 protein coding gene Chr5:93334076-93367417 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028431
 protein coding gene Chr5:94994073-95028332 (-)
WSB/EiJ MGP_WSBEiJ_G0028956
 protein coding gene Chr5:97649999-97680018 (-)



Homology
more
  • Human Ortholog
    PAQR3, progestin and adipoQ receptor family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAQR3, progestin and adipoQ receptor family member 3
  • Synonyms
    RKTG
  • Links
    NCBI Gene ID: 152559
    neXtProt AC: NX_Q6TCH7
    UniProt: Q6TCH7

  • Chr Location
    4q21.21; chr4:78887076-78939438 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted deletion of this gene causes faster chemical carcinogen-induced skin cell proliferation, higher epidermal thickness, increased number and size of skin papillomas, shorter tumor latency and delayed tumor regression. Heterozygotes develop tumors earlier and more frequently than control mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    27
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055725 Ensembl Gene Model | MGI Sequence Detail 29268 C57BL/6J ±  kb
    transcript ENSMUST00000069453 Ensembl | MGI Sequence Detail 1375 Not Applicable  
    polypeptide ENSMUSP00000069324 Ensembl | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917996
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:355673 Qiu J, et al., PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARgamma degradation. Lab Invest. 2022 Oct;102(10):1121-1131
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory