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Hcrtr2 Gene Detail
Summary
  • Symbol
    Hcrtr2
  • Name
    hypocretin (orexin) receptor 2
  • Synonyms
    mOX2aR, mOX2bR, mOXR2, OX2r
  • Feature Type
    protein coding gene
  • IDs
    MGI:2680765
    NCBI Gene: 387285
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:76133162-76230905 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2734 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2680765
 protein coding gene Chr9:76133162-76231138 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035048
 protein coding gene Chr9:76586594-76693124 (-)
A/J MGP_AJ_G0035029
 protein coding gene Chr9:73900083-74010104 (-)
AKR/J MGP_AKRJ_G0034958
 protein coding gene Chr9:75678069-75786477 (-)
BALB/cJ MGP_BALBcJ_G0035021
 protein coding gene Chr9:73569983-73682055 (-)
C3H/HeJ MGP_C3HHeJ_G0034730
 protein coding gene Chr9:76136246-76248554 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035539
 protein coding gene Chr9:78619298-78733213 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032450
 protein coding gene Chr9:73228862-73327145 (-)
CAST/EiJ MGP_CASTEiJ_G0034052
 protein coding gene Chr9:76490817-76601342 (-)
CBA/J MGP_CBAJ_G0034702
 protein coding gene Chr9:81317586-81441761 (-)
DBA/2J MGP_DBA2J_G0034862
 protein coding gene Chr9:73565536-73676418 (-)
FVB/NJ MGP_FVBNJ_G0034804
 protein coding gene Chr9:72859696-72962012 (-)
LP/J MGP_LPJ_G0034943
 protein coding gene Chr9:76817926-76924813 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034845
 protein coding gene Chr9:82417108-82548364 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035562
 protein coding gene Chr9:75835109-75947536 (-)
PWK/PhJ MGP_PWKPhJ_G0033756
 protein coding gene Chr9:73835567-73935825 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033589
 protein coding gene Chr9:76073476-76180090 (-)
WSB/EiJ MGP_WSBEiJ_G0034164
 protein coding gene Chr9:75757026-75861409 (-)



Homology
more
  • Human Ortholog
    HCRTR2, hypocretin receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCRTR2, hypocretin receptor 2
  • Synonyms
    ORXR2, OX2R, OXR2
  • Links
    NCBI Gene ID: 3062
    neXtProt AC: NX_O43614
    UniProt: O43614

  • Chr Location
    6p12.1; chr6:55106460-55284713 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hcrtr2 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice bearing targeted mutations in this gene exhibit fragmentation of sleep/wake states with similarity to narcolepsy and rare or very rare episodes of cataplexy. In addition, mice homozygous for a funtionally null allele display enhanced depression-likebehavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    16
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387285 NCBI Gene Model | MGI Sequence Detail 97744 C57BL/6J ±  kb
    transcript NM_198962 RefSeq | MGI Sequence Detail 3773 C57BL/6  
    polypeptide P58308 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 4
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 9
      Phenotypes 34
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:345716 Tsuneoka Y, et al., Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized by Branched In Situ Hybridization Chain Reaction. eNeuro. 2024 Feb;11(2):ENEURO.0474-23.2024
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory