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Pigl Gene Detail
Summary
  • Symbol
    Pigl
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class L
  • Synonyms
    LOC327942
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681271
    NCBI Gene: 327942
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:62349286-62405243 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 38.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1627 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681271
 protein coding gene Chr11:62349267-62406863 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018454
 protein coding gene Chr11:62499686-62560252 (+)
A/J MGP_AJ_G0018423
 protein coding gene Chr11:60189422-60246810 (+)
AKR/J MGP_AKRJ_G0018393
 protein coding gene Chr11:62044085-62103810 (+)
BALB/cJ MGP_BALBcJ_G0018394
 protein coding gene Chr11:60471294-60529045 (+)
C3H/HeJ MGP_C3HHeJ_G0018207
 protein coding gene Chr11:62025186-62085787 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018846
 protein coding gene Chr11:64460760-64523285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016492
 protein coding gene Chr11:57284284-57341659 (+)
CAST/EiJ MGP_CASTEiJ_G0017764
 protein coding gene Chr11:62153230-62221806 (+)
CBA/J MGP_CBAJ_G0018181
 protein coding gene Chr11:67262962-67329920 (+)
DBA/2J MGP_DBA2J_G0018290
 protein coding gene Chr11:59739224-59802723 (+)
FVB/NJ MGP_FVBNJ_G0018281
 protein coding gene Chr11:59415440-59472769 (+)
LP/J MGP_LPJ_G0018363
 protein coding gene Chr11:63047520-63108865 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018305
 protein coding gene Chr11:68239578-68309086 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018887
 protein coding gene Chr11:62194630-62256021 (+)
PWK/PhJ MGP_PWKPhJ_G0017537
 protein coding gene Chr11:60362266-60424653 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017327
 protein coding gene Chr11:62037571-62105634 (+)
WSB/EiJ MGP_WSBEiJ_G0017816
 protein coding gene Chr11:61795854-61869244 (+)



Homology
more
  • Human Ortholog
    PIGL, phosphatidylinositol glycan anchor biosynthesis class L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGL, phosphatidylinositol glycan anchor biosynthesis class L
  • Synonyms
    CHIME
  • Links
    NCBI Gene ID: 9487
    neXtProt AC: NX_Q9Y2B2
    UniProt: Q9Y2B2

  • Chr Location
    17p11.2; chr17:16217191-16351797 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PIGL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal visceral yolk sac morphology, defects in placentation with abnormal trophoblast layer formation, and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014245 Ensembl Gene Model | MGI Sequence Detail 55958 C57BL/6J ±  kb
    transcript ENSMUST00000014389 Ensembl | MGI Sequence Detail 2174 Not Applicable  
    polypeptide ENSMUSP00000014389 Ensembl | MGI Sequence Detail 252 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012699 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
      (term hierarchy)
    • EC
      3.5.1.89
    • InterPro Domains
      IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related
      IPR024078 Putative deacetylase LmbE-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 2
      cDNA 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685583
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory