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Efcab12 Gene Detail
Summary
  • Symbol
    Efcab12
  • Name
    EF-hand calcium binding domain 12
  • Synonyms
    BC060267, MGC:69711
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681834
    NCBI Gene: 212516
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115787695-115815177 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    703 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681834
 protein coding gene Chr6:115787695-115815373 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031156
 protein coding gene Chr6:118460678-118482806 (-)
A/J MGP_AJ_G0031126
 protein coding gene Chr6:113911184-113934459 (-)
AKR/J MGP_AKRJ_G0031056
 protein coding gene Chr6:116970435-116992384 (-)
BALB/cJ MGP_BALBcJ_G0031136
 protein coding gene Chr6:113717958-113740574 (-)
C3H/HeJ MGP_C3HHeJ_G0030572
 protein coding gene Chr6:67308810-67331682 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031595
 protein coding gene Chr6:121475505-121505807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028759
 protein coding gene Chr6:110914690-110937124 (-)
CAST/EiJ MGP_CASTEiJ_G0030243
 protein coding gene Chr6:117341026-117365794 (-)
CBA/J MGP_CBAJ_G0030822
 protein coding gene Chr6:126252569-126274477 (-)
DBA/2J MGP_DBA2J_G0030976
 protein coding gene Chr6:112833302-112855916 (-)
FVB/NJ MGP_FVBNJ_G0030929
 protein coding gene Chr6:112012745-112034979 (-)
LP/J MGP_LPJ_G0031055
 protein coding gene Chr6:118471024-118493131 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030964
 protein coding gene Chr6:130420525-130442671 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031623
 protein coding gene Chr6:116992080-117015141 (-)
PWK/PhJ MGP_PWKPhJ_G0029959
 protein coding gene Chr6:111848671-111871313 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029787
 protein coding gene Chr6:115708518-115732238 (-)
WSB/EiJ MGP_WSBEiJ_G0030327
 protein coding gene Chr6:117255273-117278779 (-)



Homology
more
  • Human Ortholog
    EFCAB12, EF-hand calcium binding domain 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFCAB12, EF-hand calcium binding domain 12
  • Synonyms
    C3orf25
  • Links
    NCBI Gene ID: 90288
    neXtProt AC: NX_Q6NXP0
    UniProt: Q6NXP0

  • Chr Location
    3q21.3; chr3:129401321-129428636 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    8
  • Endonuclease-mediated
    1
  • Gene trapped
    5
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Efcab12
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    43 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    4
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 212516 NCBI Gene Model | MGI Sequence Detail 27483 C57BL/6J ±  kb
transcript NM_001110506 RefSeq | MGI Sequence Detail 2350 C57BL/6  
polypeptide NP_001103976 RefSeq | MGI Sequence Detail 673 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR042847 EF-hand calcium-binding domain-containing protein 12
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141728
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory