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Polr3a Gene Detail
Summary
  • Symbol
    Polr3a
  • Name
    polymerase (RNA) III (DNA directed) polypeptide A
  • Synonyms
    9330175N20Rik, MGC:62420, RPC1, RPC155
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681836
    NCBI Gene: 218832
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:24498764-24537126 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 14.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1329 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681836
 protein coding gene Chr14:24498762-24537126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021063
 protein coding gene Chr14:17389384-17428908 (-)
A/J MGP_AJ_G0021012
 protein coding gene Chr14:16959636-16997925 (-)
AKR/J MGP_AKRJ_G0020989
 protein coding gene Chr14:17574837-17616968 (-)
BALB/cJ MGP_BALBcJ_G0021015
 protein coding gene Chr14:17059389-17097976 (-)
C3H/HeJ MGP_C3HHeJ_G0020799
 protein coding gene Chr14:17502851-17543724 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021448
 protein coding gene Chr14:17963831-18002168 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019016
 protein coding gene Chr14:17159931-17199269 (-)
CAST/EiJ MGP_CASTEiJ_G0020323
 protein coding gene Chr14:17352512-17397139 (-)
CBA/J MGP_CBAJ_G0020765
 protein coding gene Chr14:18854190-18892576 (-)
DBA/2J MGP_DBA2J_G0020888
 protein coding gene Chr14:16776744-16815779 (-)
FVB/NJ MGP_FVBNJ_G0020871
 protein coding gene Chr14:16638992-16677330 (-)
LP/J MGP_LPJ_G0020964
 protein coding gene Chr14:17671159-17709521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020897
 protein coding gene Chr14:18566807-18613311 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021481
 protein coding gene Chr14:17381875-17420261 (-)
PWK/PhJ MGP_PWKPhJ_G0020072
 protein coding gene Chr14:16361234-16404080 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019894
 protein coding gene Chr14:17186393-17238615 (-)
WSB/EiJ MGP_WSBEiJ_G0020379
 protein coding gene Chr14:17369046-17410352 (-)



Homology
more
  • Human Ortholog
    POLR3A, RNA polymerase III subunit A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR3A, RNA polymerase III subunit A
  • Synonyms
    ADDH, C160, HLD7, hRPC155, RPC1, RPC155, WDRTS
  • Links
    NCBI Gene ID: 11128
    neXtProt AC: NX_O14802
    UniProt: O14802

  • Chr Location
    10q22.3; chr10:77953148-78029522 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human POLR3A associations

Human Disease Mouse Models
      
IDs
 View 2 "NOT" models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are embryonically lethal. Surprisingly, mice homozygous for the G672E hypomyelinating leukodystrophy mutation show no evidence of hypomyelination, cerebellar atrophy, Purkinje cell loss or significant motor dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025280 Ensembl Gene Model | MGI Sequence Detail 38363 C57BL/6J ±  kb
    transcript ENSMUST00000026322 Ensembl | MGI Sequence Detail 4687 Not Applicable  
    polypeptide ENSMUSP00000026322 Ensembl | MGI Sequence Detail 1390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      2.7.7.6
    • InterPro Domains
      IPR035698 DNA-directed RNA polymerase III subunit RPC1, C-terminal
      IPR035697 DNA-directed RNA polymerase III subunit RPC1, N-terminal
      IPR045867 DNA-directed RNA polymerase, subunit beta-prime
      IPR000722 RNA polymerase, alpha subunit
      IPR006592 RNA polymerase, N-terminal
      IPR044893 RNA polymerase Rpb1, clamp domain superfamily
      IPR007080 RNA polymerase Rpb1, domain 1
      IPR007066 RNA polymerase Rpb1, domain 3
      IPR042102 RNA polymerase Rpb1, domain 3 superfamily
      IPR007083 RNA polymerase Rpb1, domain 4
      IPR007081 RNA polymerase Rpb1, domain 5
      IPR038120 RNA polymerase Rpb1, funnel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1924764
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory