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Rxfp1 Gene Detail
Summary
  • Symbol
    Rxfp1
  • Name
    relaxin/insulin-like family peptide receptor 1
  • Synonyms
    Lgr7, LOC381489
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682211
    NCBI Gene: 381489
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:79548918-79645187 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 34.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682211
 protein coding gene Chr3:79548910-79645258 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027316
 protein coding gene Chr3:79344776-79448618 (-)
A/J MGP_AJ_G0027278
 protein coding gene Chr3:76754828-76851064 (-)
AKR/J MGP_AKRJ_G0027246
 protein coding gene Chr3:78518176-78614140 (-)
BALB/cJ MGP_BALBcJ_G0027289
 protein coding gene Chr3:76778966-76881362 (-)
C3H/HeJ MGP_C3HHeJ_G0027033
 protein coding gene Chr3:78852324-78954655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027735
 protein coding gene Chr3:82366207-82473406 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025088
 protein coding gene Chr3:72386740-72775303 (-)
CAST/EiJ MGP_CASTEiJ_G0026480
 protein coding gene Chr3:78917009-79018975 (-)
CBA/J MGP_CBAJ_G0027008
 protein coding gene Chr3:85098360-85207631 (-)
DBA/2J MGP_DBA2J_G0027144
 protein coding gene Chr3:76309946-76417822 (-)
FVB/NJ MGP_FVBNJ_G0027112
 protein coding gene Chr3:74653293-74749809 (-)
LP/J MGP_LPJ_G0027252
 protein coding gene Chr3:80312897-80412145 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027131
 protein coding gene Chr3:91351056-91467467 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027793
 protein coding gene Chr3:78356676-78460292 (-)
PWK/PhJ MGP_PWKPhJ_G0026214
 protein coding gene Chr3:76064608-76165117 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026030
 protein coding gene Chr3:77504565-77612855 (-)
WSB/EiJ MGP_WSBEiJ_G0026558
 protein coding gene Chr3:78687196-78793147 (-)



Homology
more
  • Human Ortholog
    RXFP1, relaxin family peptide receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RXFP1, relaxin family peptide receptor 1
  • Synonyms
    LGR7, RXFPR1
  • Links
    NCBI Gene ID: 59350
    neXtProt AC: NX_Q9HBX9
    UniProt: Q9HBX9

  • Chr Location
    4q32.1; chr4:158315311-158653372 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display reduced male fertility, particularly at younger ages and early generations. Impaired nipple development prevents nursing by females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    13
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034009 Ensembl Gene Model | MGI Sequence Detail 96270 C57BL/6J ±  kb
    transcript ENSMUST00000078527 Ensembl | MGI Sequence Detail 5382 Not Applicable  
    polypeptide ENSMUSP00000077611 Ensembl | MGI Sequence Detail 758 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 8
      Primer pair 3
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685864
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:86876 Hsu SY, et al., The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol. 2000 Aug;14(8):1257-71
    • Latest
      J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory