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Rsf1 Gene Detail
Summary
  • Symbol
    Rsf1
  • Name
    remodeling and spacing factor 1
  • Synonyms
    4832420A03Rik, C030033M12Rik, Hbxap, p325, XAP8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682305
    NCBI Gene: 233532
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97229103-97341989 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682305
 protein coding gene Chr7:97229096-97341989 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032528
 protein coding gene Chr7:100286106-100400596 (+)
A/J MGP_AJ_G0032502
 protein coding gene Chr7:97796436-97911297 (+)
AKR/J MGP_AKRJ_G0032438
 protein coding gene Chr7:100129291-100247581 (+)
BALB/cJ MGP_BALBcJ_G0032513
 protein coding gene Chr7:97488451-97601698 (+)
C3H/HeJ MGP_C3HHeJ_G0032228
 protein coding gene Chr7:100476512-100598223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033011
 protein coding gene Chr7:104188738-104311883 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030006
 protein coding gene Chr7:100247242-100358343 (+)
CAST/EiJ MGP_CASTEiJ_G0031555
 protein coding gene Chr7:91993912-92118471 (+)
CBA/J MGP_CBAJ_G0032195
 protein coding gene Chr7:107697883-107825826 (+)
DBA/2J MGP_DBA2J_G0032347
 protein coding gene Chr7:96151880-96265474 (+)
FVB/NJ MGP_FVBNJ_G0032303
 protein coding gene Chr7:95942403-96059690 (+)
LP/J MGP_LPJ_G0032436
 protein coding gene Chr7:101606555-101721183 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032336
 protein coding gene Chr7:109237339-109369304 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033033
 protein coding gene Chr7:99413416-99529248 (+)
PWK/PhJ MGP_PWKPhJ_G0031273
 protein coding gene Chr7:89213122-89330000 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031116
 protein coding gene Chr7:86648836-86768988 (+)
WSB/EiJ MGP_WSBEiJ_G0031672
 protein coding gene Chr7:100056653-100171320 (+)



Homology
more
  • Human Ortholog
    RSF1, remodeling and spacing factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSF1, remodeling and spacing factor 1
  • Synonyms
    HBXAP, p325, RSF-1, XAP8
  • Links
    NCBI Gene ID: 51773
    neXtProt AC: NX_Q96T23
    UniProt: Q96T23

  • Chr Location
    11q14.1; chr11:77660009-77872232 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons exhibit increased susceptibility to etoposide-induced neuron apoptosis with failure to repair double-strand breaks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    47
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233532 NCBI Gene Model | MGI Sequence Detail 112887 C57BL/6J ±  kb
    transcript NM_001081267 RefSeq | MGI Sequence Detail 11129 C57BL/6  
    polypeptide NP_001074736 RefSeq | MGI Sequence Detail 1441 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR028938 Remodeling and spacing factor 1-like
      IPR028942 WHIM1 domain
      IPR011011 Zinc finger, FYVE/PHD-type
      IPR019787 Zinc finger, PHD-finger
      IPR001965 Zinc finger, PHD-type
      IPR019786 Zinc finger, PHD-type, conserved site
      IPR013083 Zinc finger, RING/FYVE/PHD-type
    • GlyGen
      E9PWW9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1924584, MGI:2444367, MGI:2685010
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 36
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory