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Tmprss13 Gene Detail
Summary
  • Symbol
    Tmprss13
  • Name
    transmembrane protease, serine 13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682935
    NCBI Gene: 214531
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45230398-45258879 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1084 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682935
protein coding gene Chr9:45230286-45258879 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034736
protein coding gene Chr9:43870202-43900345 (+)
A/J MGP_AJ_G0034717
protein coding gene Chr9:42648920-42677694 (+)
AKR/J MGP_AKRJ_G0034644
protein coding gene Chr9:43523904-43552909 (+)
BALB/cJ MGP_BALBcJ_G0034708
protein coding gene Chr9:42378304-42407182 (+)
C3H/HeJ MGP_C3HHeJ_G0034419
protein coding gene Chr9:43982192-44011673 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035229
protein coding gene Chr9:45160825-45189154 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032143
protein coding gene Chr9:42197756-42226591 (+)
CAST/EiJ MGP_CASTEiJ_G0033741
protein coding gene Chr9:43841629-43870366 (+)
CBA/J MGP_CBAJ_G0034391
protein coding gene Chr9:46801576-46835714 (+)
DBA/2J MGP_DBA2J_G0034550
protein coding gene Chr9:42533677-42562178 (+)
FVB/NJ MGP_FVBNJ_G0034491
protein coding gene Chr9:41793402-41823836 (+)
LP/J MGP_LPJ_G0034631
protein coding gene Chr9:44181555-44210211 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034535
protein coding gene Chr9:48619268-48651824 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035250
protein coding gene Chr9:43442452-43471055 (+)
PWK/PhJ MGP_PWKPhJ_G0033446
protein coding gene Chr9:42423149-42452340 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033282
protein coding gene Chr9:43745516-43775661 (+)
WSB/EiJ MGP_WSBEiJ_G0033854
protein coding gene Chr9:43475267-43505088 (+)



Homology
more
  • Human Ortholog
    TMPRSS13, transmembrane serine protease 13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS13, transmembrane serine protease 13
  • Synonyms
    MSP, MSPL, MSPS, TMPRSS11
  • Links
    NCBI Gene ID: 84000
    neXtProt AC: NX_Q9BYE2
    UniProt: Q9BYE2

  • Chr Location
    11q23.3; chr11:117900641-117929459 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and outwardly healthy but exhibit abnormal stratum corneum formation leading to impaired skin barrier function, as measured by the transepidermal fluid loss rate in newborn pups.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037129 Ensembl Gene Model | MGI Sequence Detail 28482 C57BL/6J ±  kb
    transcript ENSMUST00000034597 Ensembl | MGI Sequence Detail 3245 Not Applicable  
    polypeptide ENSMUSP00000034597 Ensembl | MGI Sequence Detail 548 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:298935 Murray AS, et al., The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy. Oncogene. 2020 Oct;39(41):6421-6436

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory