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Raz Cytogenetic Marker Detail
Summary
  • Symbol
    Raz
  • Name
    replicated anterior zeugopod, inversion
  • Synonyms
    In(5)1GSF
  • Feature Type
    chromosomal inversion
  • IDs
    MGI:2683724
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 5, Syntenic
  • Mapping Data
    1 experiment
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
This chromosomal inversion in the homozygous state results in neonatal lethality with dysmorphologies visible in the brain, eye and heart. Abnormal signaling in the limb bud leads to gross abnormalities in limb development for homozygous mutants. Polydactyly is seen in heterozygous mice.
References
more
  • Summaries
    All 2
    Phenotypes 1
  • Earliest
    J:87042 Krebs O, et al., Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud. Development. 2003 Dec;130(24):6037-47
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory