Klhl29 MGI Mouse Gene Detail - MGI:2683857

Symbol

Klhl29
Name

kelch-like 29
Synonyms

A230106N14Rik, Kbtbd9, mKIAA1921

Feature Type

protein coding gene
IDs

MGI:2683857
NCBI Gene: 208439
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:5127472-5425682 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 2.28 cM
Mapping Data

2 experiments

SNPs within 2kb

7022 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2683857	protein coding gene	Chr12:5127465-5425682 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019580	protein coding gene	Chr12:2001427-2222690 (-)
A/J	MGP_AJ_G0019547	protein coding gene	Chr12:1957125-2255000 (-)
AKR/J	MGP_AKRJ_G0019517	protein coding gene	Chr12:2176131-2397660 (-)
BALB/cJ	MGP_BALBcJ_G0019522	protein coding gene	Chr12:2012963-2310350 (-)
C3H/HeJ	MGP_C3HHeJ_G0019328	protein coding gene	Chr12:1948589-2260646 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019971	protein coding gene	Chr12:2055413-2374378 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017596	protein coding gene	Chr12:1930708-2154338 (-)
CAST/EiJ	MGP_CASTEiJ_G0018883	protein coding gene	Chr12:1995666-2330352 (-)
CBA/J	MGP_CBAJ_G0019299	protein coding gene	Chr12:2387265-2708965 (-)
DBA/2J	MGP_DBA2J_G0019412	protein coding gene	Chr12:1897086-2113919 (-)
FVB/NJ	MGP_FVBNJ_G0019403	protein coding gene	Chr12:1918035-2132813 (-)
LP/J	MGP_LPJ_G0019483	protein coding gene	Chr12:2011448-2232588 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019436	protein coding gene	Chr12:2127388-2350293 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020010	protein coding gene	Chr12:1985238-2209212 (-)
PWK/PhJ	MGP_PWKPhJ_G0018649	protein coding gene	Chr12:1919923-2262511 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018440	protein coding gene	Chr12:2025295-2340691 (-)
WSB/EiJ	MGP_WSBEiJ_G0018934	protein coding gene	Chr12:1975708-2281203 (-)

Human Ortholog

KLHL29, kelch like family member 29

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL29, kelch like family member 29
Synonyms

KBTBD9
Links

HGNC:29404

NCBI Gene ID: 114818

neXtProt AC: NX_Q96CT2

UniProt: Q96CT2
Chr Location

2p24.1; chr2:23385179-23708611 (+) GRCh38

MGI Vertebrate Homology

Klhl29 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KLHL29
Gene Tree

Klhl29

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

866
Tissues

13
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl29

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All Sequences

39
RefSeq

3
UniProt

3
CCDS

CCDS49021.1

Ensembl

ENSMUSG00000020627 (Evidence)
NCBI Gene

208439

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020627	Ensembl Gene Model \| MGI Sequence Detail	298211	C57BL/6J	± kb
transcript	ENSMUST00000020958	Ensembl \| MGI Sequence Detail	7041	Not Applicable
polypeptide	ENSMUSP00000020958	Ensembl \| MGI Sequence Detail	875	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009390 kelch-like protein 29

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR000210 BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 2

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MGI:2684914

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 9
Earliest

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Klhl29:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115682	Chr12:5425711-5425735 (-)	-41 bp
Tssr115681	Chr12:5425688-5425705 (-)	-15 bp
Tssr115680	Chr12:5417918-5417921 (-)	7,762 bp
Tssr115679	Chr12:5384637-5384641 (-)	41,043 bp
Tssr115678	Chr12:5296840-5296870 (-)	128,827 bp
Tssr115677	Chr12:5251121-5251123 (-)	174,560 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24