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Ffar1 Gene Detail
Summary
  • Symbol
    Ffar1
  • Name
    free fatty acid receptor 1
  • Synonyms
    Gpr40
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684079
    NCBI Gene: 233081
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:30559993-30560895 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684079
 protein coding gene Chr7:30556815-30560989 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032048
 protein coding gene Chr7:29888645-29892730 (-)
A/J MGP_AJ_G0032025
 protein coding gene Chr7:29066292-29070433 (-)
AKR/J MGP_AKRJ_G0031958
 protein coding gene Chr7:29810284-29814444 (-)
BALB/cJ MGP_BALBcJ_G0032032
 protein coding gene Chr7:29255612-29259727 (-)
C3H/HeJ MGP_C3HHeJ_G0031751
 protein coding gene Chr7:30272046-30276458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032498
 protein coding gene Chr7:30869717-30874001 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029548
 protein coding gene Chr7:30076747-30081109 (-)
CAST/EiJ MGP_CASTEiJ_G0031085
 protein coding gene Chr7:23536433-23544987 (-)
CBA/J MGP_CBAJ_G0031717
 protein coding gene Chr7:32342267-32346394 (-)
DBA/2J MGP_DBA2J_G0031869
 protein coding gene Chr7:28810234-28814607 (-)
FVB/NJ MGP_FVBNJ_G0031826
 protein coding gene Chr7:28924304-28928446 (-)
LP/J MGP_LPJ_G0031950
 protein coding gene Chr7:30205760-30211959 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031862
 protein coding gene Chr7:31573676-31578008 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032526
 protein coding gene Chr7:29318848-29323065 (-)
PWK/PhJ MGP_PWKPhJ_G0030809
 protein coding gene Chr7:23831126-23835427 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030644
 protein coding gene Chr7:20326466-20330617 (-)
WSB/EiJ MGP_WSBEiJ_G0031195
 protein coding gene Chr7:29725653-29730977 (-)



Homology
more
  • Human Ortholog
    FFAR1, free fatty acid receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FFAR1, free fatty acid receptor 1
  • Synonyms
    FFA1R, GPCR40, GPR40
  • Links
    NCBI Gene ID: 2864
    neXtProt AC: NX_O14842
    UniProt: O14842

  • Chr Location
    19q13.12; chr19:35347902-35353864 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FFAR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 7 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
There are conflicting reports on the metabolic affects of disrupting this gene. Glucose metabolism lipid levels have been studied.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    10
  • cDNA Data
    5
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233081 NCBI Gene Model | MGI Sequence Detail 903 C57BL/6J ±  kb
    transcript NM_194057 RefSeq | MGI Sequence Detail 903 C57BL/6  
    polypeptide Q76JU9 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      Genomic 1
      cDNA 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 35
    • Earliest
      J:85392 Briscoe CP, et al., The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem. 2003 Mar 28;278(13):11303-11
    • Latest
      J:345929 Koganesawa M, et al., Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment. Immunology. 2024 Feb 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory