Mrgpra3 MGI Mouse Gene Detail - MGI:2684085 - MAS-related GPR, member A3

Mrgpra3 Gene Detail

Symbol

Mrgpra3
Name

MAS-related GPR, member A3
Synonyms

G protein-coupled receptor, MrgA3

Feature Type

protein coding gene
IDs

MGI:2684085
NCBI Gene: 233222
Alliance

gene page

Sequence Map

Chr7:47238698-47251120 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 30.91 cM
Mapping Data

1 experiment

SNPs within 2kb

692 from dbSNP Build 142
Strain Annotations

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684085	protein coding gene	Chr7:47238698-47251120 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0032768	protein coding gene	Chr7:50344209-50357588 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0032785	protein coding gene	Chr7:47675578-47895945 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

MRGPRX1, MAS related GPR family member X1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRGPRX1, MAS related GPR family member X1
Synonyms

GPCR, MGRG2, MRGX1, SNSR4
Links

HGNC:17962

NCBI Gene ID: 259249

neXtProt AC: NX_Q96LB2

UniProt: Q96LB2
Chr Location

11p15.1,11; chr11:18933499-18939414 (-) GRCh38

Human Ortholog

MRGPRX2, MAS related GPR family member X2
Synonyms

MGRG3, MRGX2
Links

HGNC:17983

NCBI Gene ID: 117194

neXtProt AC: NX_Q96LB1

UniProt: Q96LB1
Chr Location

11p15.1; chr11:19054455-19060717 (-) GRCh38

Human Ortholog

MRGPRX3, MAS related GPR family member X3
Synonyms

GPCR, MRGX3, SNSR1, SNSR2
Links

HGNC:17980

NCBI Gene ID: 117195

neXtProt AC: NX_Q96LB0

UniProt: Q96LB0
Chr Location

11p15.1; chr11:18120955-18138488 (+) GRCh38

Human Ortholog

MRGPRX4, MAS related GPR family member X4
Synonyms

GPCR, MRGX4, SNSR6
Links

HGNC:17617

NCBI Gene ID: 117196

neXtProt AC: NX_Q96LA9

UniProt: Q96LA9
Chr Location

11p15.1; chr11:18172837-18174280 (+) GRCh38

MGI Vertebrate Homology

Mrgpra3 stringent orthology
4 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MRGPRX1, MRGPRX2, MRGPRX3, MRGPRX4
Gene Tree

Mrgpra3

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Phenotype Summary

16 phenotype references

All Mutations and Alleles

4
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

1 involving Mrgpra3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

12
RefSeq

2
UniProt

2
CCDS

CCDS21297.2

Ensembl

ENSMUSG00000078698 (Evidence)
NCBI Gene

233222

			Length	Strain/Species	Flank
genomic	233222	NCBI Gene Model \| MGI Sequence Detail	12423	C57BL/6J	± kb
transcript	NM_153067	RefSeq \| MGI Sequence Detail	1295	C57BL/6
polypeptide	Q91WW3	UniProt \| EBI \| MGI Sequence Detail	302	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001689 Mas-related G-protein coupled receptor A3

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR026233 Mas-related G protein-coupled receptor A

IPR026234 Mas-related G protein-coupled receptor family
GlyGen

Q91WW3 3 sites

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All nucleic 3

Other 3

Microarray probesets 2

Summaries

All 41

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 16
Earliest

J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
Latest

J:343323 Deng L, et al., S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Cell. 2023 Nov 22;186(24):5375-5393.e25

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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