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Slc39a2 Gene Detail
Summary
  • Symbol
    Slc39a2
  • Name
    solute carrier family 39 (zinc transporter), member 2
  • Synonyms
    F730005G13Rik, zip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684326
    NCBI Gene: 214922
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52130539-52134202 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684326
 protein coding gene Chr14:52130346-52134202 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021282
 protein coding gene Chr14:45914581-45918468 (+)
A/J MGP_AJ_G0021239
 protein coding gene Chr14:44720471-44724196 (+)
AKR/J MGP_AKRJ_G0021215
 protein coding gene Chr14:46336797-46340530 (+)
BALB/cJ MGP_BALBcJ_G0021243
 protein coding gene Chr14:44827659-44831740 (+)
C3H/HeJ MGP_C3HHeJ_G0021023
 protein coding gene Chr14:46142490-46146447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021682
 protein coding gene Chr14:47926241-47930999 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019227
 protein coding gene Chr14:43910963-43914837 (+)
CAST/EiJ MGP_CASTEiJ_G0020542
 protein coding gene Chr14:43102630-43107770 (+)
CBA/J MGP_CBAJ_G0020990
 protein coding gene Chr14:49387289-49390962 (+)
DBA/2J MGP_DBA2J_G0021111
 protein coding gene Chr14:44483069-44486784 (+)
FVB/NJ MGP_FVBNJ_G0021094
 protein coding gene Chr14:44067392-44071306 (+)
LP/J MGP_LPJ_G0021186
 protein coding gene Chr14:46510661-46517863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021117
 protein coding gene Chr14:48836744-48840408 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021709
 protein coding gene Chr14:45724306-45728002 (+)
PWK/PhJ MGP_PWKPhJ_G0020291
 protein coding gene Chr14:41231472-41235376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020118
 protein coding gene Chr14:41748867-41752674 (+)
WSB/EiJ MGP_WSBEiJ_G0020595
 protein coding gene Chr14:46021776-46026361 (+)



Homology
more
  • Human Ortholog
    SLC39A2, solute carrier family 39 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC39A2, solute carrier family 39 member 2
  • Synonyms
    6A1, ETI-1, ZIP-2, ZIP2
  • Links
    NCBI Gene ID: 29986
    neXtProt AC: NX_Q9NP94
    UniProt: Q9NP94

  • Chr Location
    14q11.2; chr14:20999255-21001871 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are overtly normal when fed a zinc-replete diet but show increased sensitivity to the effects of maternal dietary zinc deficiency during pregnancy. Resulting embryos are often growth retarded with craniofacial and limb defects, and show altered iron and calcium levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    30
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214922 NCBI Gene Model | MGI Sequence Detail 3664 C57BL/6J ±  kb
    transcript NM_001039676 RefSeq | MGI Sequence Detail 2334 C57BL/6  
    polypeptide G3X943 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 7
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685135, MGI:2686635
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:87178 Dufner-Beattie J, et al., Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003 Dec 12;278(50):50142-50
    • Latest
      J:294482 Du L, et al., The critical role of the zinc transporter Zip2 (SLC39A2) in ischemia/reperfusion injury in mouse hearts. J Mol Cell Cardiol. 2019 Jul;132:136-145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory