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Arap2 Gene Detail
Summary
  • Symbol
    Arap2
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Synonyms
    Centd1, mKIAA0580
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684416
    NCBI Gene: 212285
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:62759788-62923502 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 32.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4487 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684416
 protein coding gene Chr5:62759788-62923874 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029560
 protein coding gene Chr5:62125577-62283760 (-)
A/J MGP_AJ_G0029528
 protein coding gene Chr5:59767513-59941276 (-)
AKR/J MGP_AKRJ_G0029476
 protein coding gene Chr5:61644011-61827491 (-)
BALB/cJ MGP_BALBcJ_G0029537
 protein coding gene Chr5:60462505-60628281 (-)
C3H/HeJ MGP_C3HHeJ_G0029260
 protein coding gene Chr5:61990063-62160038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029991
 protein coding gene Chr5:64699067-64880060 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027231
 protein coding gene Chr5:55992504-56157152 (-)
CAST/EiJ MGP_CASTEiJ_G0028668
 protein coding gene Chr5:61074554-61253241 (-)
CBA/J MGP_CBAJ_G0029229
 protein coding gene Chr5:66759692-66930101 (-)
DBA/2J MGP_DBA2J_G0029375
 protein coding gene Chr5:59833433-59984086 (-)
FVB/NJ MGP_FVBNJ_G0029335
 protein coding gene Chr5:59031370-59199827 (-)
LP/J MGP_LPJ_G0029460
 protein coding gene Chr5:62588918-62758166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029363
 protein coding gene Chr5:69581929-69782832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030024
 protein coding gene Chr5:61376716-61556046 (-)
PWK/PhJ MGP_PWKPhJ_G0028392
 protein coding gene Chr5:58850226-59020262 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028226
 protein coding gene Chr5:60737781-60904677 (-)
WSB/EiJ MGP_WSBEiJ_G0028749
 protein coding gene Chr5:61554991-61729069 (-)



Homology
more
  • Human Ortholog
    ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Synonyms
    CENTD1, PARX
  • Links
    NCBI Gene ID: 116984
    neXtProt AC: NX_Q8WZ64
    UniProt: Q8WZ64

  • Chr Location
    4p14; chr4:35948221-36244784 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    46
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037999 Ensembl Gene Model | MGI Sequence Detail 163715 C57BL/6J ±  kb
transcript ENSMUST00000076623 Ensembl | MGI Sequence Detail 7306 Not Applicable  
polypeptide ENSMUSP00000075924 Ensembl | MGI Sequence Detail 1703 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004194 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR037858 ARAP, RhoGAP domain
    IPR038508 ArfGAP domain superfamily
    IPR037278 ARFGAP/RecO-like zinc finger
    IPR052227 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein
    IPR001164 Arf GTPase activating protein
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR000159 Ras-associating domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
  • GlyGen
    Q8BZ05 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 4
Other
Accession IDs
less
MGI:2684994
References
more
  • Summaries
    All 56
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory