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Syna Gene Detail
Summary
  • Symbol
    Syna
  • Name
    syncytin a
  • Synonyms
    Gm52, syncytin-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684898
    NCBI Gene: 214292
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:134587000-134589025 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684898
 protein coding gene Chr5:134586108-134605891 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030158
 protein coding gene Chr5:138970271-138972296 (-)
A/J MGP_AJ_G0030126
 protein coding gene Chr5:133073367-133075392 (-)
AKR/J MGP_AKRJ_G0030059
 protein coding gene Chr5:137390637-137392662 (-)
BALB/cJ MGP_BALBcJ_G0030136
 protein coding gene Chr5:134409442-134411467 (-)
C3H/HeJ MGP_C3HHeJ_G0029852
 protein coding gene Chr5:137927475-137929500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030589
 protein coding gene Chr5:144194400-144196425 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027813
 protein coding gene Chr5:127353428-127355451 (-)
CAST/EiJ MGP_CASTEiJ_G0029261
 protein coding gene Chr5:137367486-137369501 (-)
CBA/J MGP_CBAJ_G0029822
 protein coding gene Chr5:149822074-149824099 (-)
DBA/2J MGP_DBA2J_G0029973
 protein coding gene Chr5:132969613-132971638 (-)
FVB/NJ MGP_FVBNJ_G0029928
 protein coding gene Chr5:132102977-132105002 (-)
LP/J MGP_LPJ_G0030061
 protein coding gene Chr5:139446985-139449010 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029960
 protein coding gene Chr5:152893574-152895599 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030629
 protein coding gene Chr5:137111666-137113691 (-)
PWK/PhJ MGP_PWKPhJ_G0028976
 protein coding gene Chr5:131995178-131997193 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028811
 protein coding gene Chr5:134694302-134696326 (-)
WSB/EiJ MGP_WSBEiJ_G0029335
 protein coding gene Chr5:137864149-137866174 (-)



Homology
more
  • Human Ortholog
    ERVFRD-1, endogenous retrovirus group FRD member 1, envelope
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERVFRD-1, endogenous retrovirus group FRD member 1, envelope
  • Synonyms
    envFRD, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191
  • Links
    NCBI Gene ID: 405754
    neXtProt AC: NX_P60508
    UniProt: P60508

  • Chr Location
    6p24.2; chr6:11102324-11111845 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    5 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality between E11.5 and E14.5 associated with defective placental layrinth formation, impaired placental transport, and increased trophoblast cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    65
  • cDNA Data
    4
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000085957 Ensembl Gene Model | MGI Sequence Detail 2026 C57BL/6J ±  kb
    transcript ENSMUST00000149604 Ensembl | MGI Sequence Detail 2026 Not Applicable  
    polypeptide ENSMUSP00000116437 Ensembl | MGI Sequence Detail 617 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR018154 TLV/ENV coat polyprotein
    • GlyGen
      Q5G5D5 3 sites
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 44
      Diseases 2
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:96249 Dupressoir A, et al., Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):725-30
    • Latest
      J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory