Stox1 MGI Mouse Gene Detail - MGI:2684909

Symbol

Stox1
Name

storkhead box 1
Synonyms

4732470K04Rik

Feature Type

protein coding gene
IDs

MGI:2684909
NCBI Gene: 216021
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:62494822-62561907 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.45 cM
Mapping Data

1 experiment

SNPs within 2kb

1635 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684909	protein coding gene	Chr10:62494822-62561907 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017304	protein coding gene	Chr10:62106938-62183435 (-)
A/J	MGP_AJ_G0017282	protein coding gene	Chr10:60200420-60268961 (-)
AKR/J	MGP_AKRJ_G0017242	protein coding gene	Chr10:61766899-61838582 (-)
BALB/cJ	MGP_BALBcJ_G0017242	protein coding gene	Chr10:60285427-60360216 (-)
C3H/HeJ	MGP_C3HHeJ_G0017065	protein coding gene	Chr10:61690548-61759977 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017700	protein coding gene	Chr10:64324094-64413617 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015390	protein coding gene	Chr10:57163972-57227975 (-)
CAST/EiJ	MGP_CASTEiJ_G0016636	protein coding gene	Chr10:61741324-61816018 (-)
CBA/J	MGP_CBAJ_G0017037	protein coding gene	Chr10:66743418-66823452 (-)
DBA/2J	MGP_DBA2J_G0017142	protein coding gene	Chr10:59474255-59543897 (-)
FVB/NJ	MGP_FVBNJ_G0017136	protein coding gene	Chr10:58740047-58811237 (-)
LP/J	MGP_LPJ_G0017216	protein coding gene	Chr10:62500728-62571657 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017164	protein coding gene	Chr10:68954408-69028193 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017738	protein coding gene	Chr10:61613184-61689744 (-)
PWK/PhJ	MGP_PWKPhJ_G0016419	protein coding gene	Chr10:59345707-59416306 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016201	protein coding gene	Chr10:60974555-61042934 (-)
WSB/EiJ	MGP_WSBEiJ_G0016700	protein coding gene	Chr10:61553029-61628518 (-)

Human Ortholog

STOX1, storkhead box 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STOX1, storkhead box 1
Synonyms

C10orf24
Links

HGNC:23508

NCBI Gene ID: 219736

neXtProt AC: NX_Q6ZVD7

UniProt: Q6ZVD7
Chr Location

10q22.1; chr10:68827531-68895432 (+) GRCh38

MGI Vertebrate Homology

Stox1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STOX1
Gene Tree

Stox1

Diseases

1 with human STOX1 associations

				Human Disease	Mouse Models
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

32
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Stox1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null pregnant mice develop gestational hypertension with placental vascular and extracellular matrix abnormalities and some placental hypoxia.

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All GO Annotations

47
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN stox1

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS48580.1

Ensembl

ENSMUSG00000036923 (Evidence)
NCBI Gene

216021

			Length	Strain/Species	Flank
genomic	216021	NCBI Gene Model \| MGI Sequence Detail	67086	C57BL/6J	± kb
transcript	NM_001033260	RefSeq \| MGI Sequence Detail	3490	Not Specified
polypeptide	B2RQL2	UniProt \| EBI \| MGI Sequence Detail	990	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015769 storkhead-box protein 1

(term hierarchy)
InterPro Domains

IPR040126 Storkhead-box protein 1/2

IPR019391 Storkhead-box protein, winged-helix domain
GlyGen

B2RQL2 1 site, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 7

Primer pair 1

Other 1

Microarray probesets 1

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:308988 Parchem JG, et al., STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects. JCI Insight. 2021 Jan 25;6(2)

TSS for Stox1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97872	Chr10:62561865-62561881 (-)	34 bp
Tssr97871	Chr10:62501148-62501171 (-)	60,747 bp
Tssr97870	Chr10:62499817-62499858 (-)	62,069 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24