Vcpkmt MGI Mouse Gene Detail - MGI:2684917 - valosin containing protein lysine (K) methyltransferase

Symbol

Vcpkmt
Name

valosin containing protein lysine (K) methyltransferase
Synonyms

Gm71, LOC207965, Mettl21d

Feature Type

protein coding gene
IDs

MGI:2684917
NCBI Gene: 207965
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:69624402-69629884 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 28.92 cM
Mapping Data

1 experiment

SNPs within 2kb

280 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684917	protein coding gene	Chr12:69623504-69629884 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019797	protein coding gene	Chr12:69278323-69283723 (-)
A/J	MGP_AJ_G0019755	protein coding gene	Chr12:66688376-66696208 (-)
AKR/J	MGP_AKRJ_G0019731	protein coding gene	Chr12:68689143-68694803 (-)
BALB/cJ	MGP_BALBcJ_G0019735	protein coding gene	Chr12:67145758-67152434 (-)
C3H/HeJ	MGP_C3HHeJ_G0019541	protein coding gene	Chr12:69151772-69158064 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020187	protein coding gene	Chr12:71495626-71501026 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017807	protein coding gene	Chr12:64232922-64238315 (-)
CAST/EiJ	MGP_CASTEiJ_G0019092	protein coding gene	Chr12:63905200-63912815 (-)
CBA/J	MGP_CBAJ_G0019510	protein coding gene	Chr12:74120499-74126223 (-)
DBA/2J	MGP_DBA2J_G0019626	protein coding gene	Chr12:66604050-66609474 (-)
FVB/NJ	MGP_FVBNJ_G0019613	protein coding gene	Chr12:65499891-65505867 (-)
LP/J	MGP_LPJ_G0019698	protein coding gene	Chr12:69221333-69226946 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019652	protein coding gene	Chr12:77450206-77455630 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020222	protein coding gene	Chr12:68158006-68163406 (-)
PWK/PhJ	MGP_PWKPhJ_G0018857	protein coding gene	Chr12:60871868-60880914 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018652	protein coding gene	Chr12:62543482-62549757 (-)
WSB/EiJ	MGP_WSBEiJ_G0019143	protein coding gene	Chr12:68794350-68800925 (-)

Human Ortholog

VCPKMT, valosin containing protein lysine methyltransferase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VCPKMT, valosin containing protein lysine methyltransferase
Synonyms

C14orf138, METTL21D, VCP-KMT
Links

HGNC:20352

NCBI Gene ID: 79609

neXtProt AC: NX_Q9H867

UniProt: Q9H867
Chr Location

14q21.3; chr14:50102716-50116600 (-) GRCh38

MGI Vertebrate Homology

Vcpkmt stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: VCPKMT
Gene Tree

Vcpkmt

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Vcpkmt
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit no abnormal phenotype.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

24

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vcpkmt

ZFIN vcpkmt

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All Sequences

50
RefSeq

11
UniProt

3
CCDS

CCDS36464.1

Ensembl

ENSMUSG00000049882 (Evidence)
NCBI Gene

207965

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049882	Ensembl Gene Model \| MGI Sequence Detail	5483	C57BL/6J	± kb
transcript	ENSMUST00000058639	Ensembl \| MGI Sequence Detail	1109	Not Applicable
polypeptide	ENSMUSP00000055002	Ensembl \| MGI Sequence Detail	228	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032613 protein N-lysine methyltransferase METTL21D

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR019410 Lysine methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 24

cDNA 24

Microarray probesets 2

Summaries

All 40

Gene Ontology 7

Phenotypes 16
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vcpkmt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116513	Chr12:69631320-69631354 (-)	-1,453 bp
Tssr116512	Chr12:69629759-69629824 (-)	92 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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