Pcdh17 MGI Mouse Gene Detail - MGI:2684924

Symbol

Pcdh17
Name

protocadherin 17
Synonyms

C030033F14Rik, LOC219228

Feature Type

protein coding gene
IDs

MGI:2684924
NCBI Gene: 219228
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:84680626-84775005 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 43.54 cM
Mapping Data

2 experiments

SNPs within 2kb

2454 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684924	protein coding gene	Chr14:84680626-84776442 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021606	protein coding gene	Chr14:79824865-79932388 (+)
A/J	MGP_AJ_G0021564	protein coding gene	Chr14:77724894-77820977 (+)
AKR/J	MGP_AKRJ_G0021540	protein coding gene	Chr14:80055815-80149304 (+)
BALB/cJ	MGP_BALBcJ_G0021570	protein coding gene	Chr14:77708029-77801321 (+)
C3H/HeJ	MGP_C3HHeJ_G0021348	protein coding gene	Chr14:79769785-79867040 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022010	protein coding gene	Chr14:83199541-83300420 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019549	protein coding gene	Chr14:75653910-75745837 (+)
CAST/EiJ	MGP_CASTEiJ_G0020865	protein coding gene	Chr14:76801141-76906404 (+)
CBA/J	MGP_CBAJ_G0021316	protein coding gene	Chr14:86025207-86117819 (+)
DBA/2J	MGP_DBA2J_G0021440	protein coding gene	Chr14:77116176-77211743 (+)
FVB/NJ	MGP_FVBNJ_G0021416	protein coding gene	Chr14:76465254-76561314 (+)
LP/J	MGP_LPJ_G0021508	protein coding gene	Chr14:80867851-80968619 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021444	protein coding gene	Chr14:85512362-85632942 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022033	protein coding gene	Chr14:79323470-79423152 (+)
PWK/PhJ	MGP_PWKPhJ_G0020608	protein coding gene	Chr14:73985229-74075593 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020445	protein coding gene	Chr14:75365528-75460425 (+)
WSB/EiJ	MGP_WSBEiJ_G0020918	protein coding gene	Chr14:79818244-79918043 (+)

Human Ortholog

PCDH17, protocadherin 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCDH17, protocadherin 17
Synonyms

PCDH68, PCH68
Links

HGNC:14267

NCBI Gene ID: 27253

neXtProt AC: NX_O14917

UniProt: O14917
Chr Location

13q21.1; chr13:57630108-57729311 (+) GRCh38

MGI Vertebrate Homology

Pcdh17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PCDH17
Gene Tree

Pcdh17

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Pcdh17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired synaptic transmission, increased synaptic vesicle number and decreased depression-related behavior.

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All GO Annotations

18
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

96
cDNA Data

17
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PCDH17

Xenbase pcdh17

ZFIN pcdh17

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All Sequences

59
RefSeq

12
UniProt

4
CCDS

CCDS27304.1

Ensembl

ENSMUSG00000035566 (Evidence)
NCBI Gene

219228

			Length	Strain/Species	Flank
genomic	219228	NCBI Gene Model \| MGI Sequence Detail	94380	C57BL/6J	± kb
transcript	NM_001013753	RefSeq \| MGI Sequence Detail	9509	C57BL/6
polypeptide	NP_001013775	RefSeq \| MGI Sequence Detail	1157	C57BL/6

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UniProt

4 Sequences
InterPro Domains

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR013164 Cadherin, N-terminal

IPR050174 Protocadherin/Cadherin-related Cell Adhesion
GlyGen

E9PXF0 6 sites, 9 N-linked glycans (6 sites)

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All nucleic 19

cDNA 17

Primer pair 2

Microarray probesets 6

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MGI:1924636

Summaries

All 39

Developmental Gene Expression 11

Gene Ontology 2

Phenotypes 6
Earliest

J:62200 Yagi T, et al., Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 2000 May 15;14(10):1169-80
Latest

J:342586 Martinez AP, et al., Pcdh19 mediates olfactory sensory neuron coalescence during postnatal stages and regeneration. iScience. 2023 Nov 17;26(11):108220

TSS for Pcdh17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126843	Chr14:84680993-84681008 (+)	375 bp
Tssr126844	Chr14:84682454-84682472 (+)	1,837 bp
Tssr4495	Chr14:84682707-84682735 (+)	2,095 bp
Tssr126845	Chr14:84682768-84682800 (+)	2,158 bp
Tssr126846	Chr14:84773981-84774000 (+)	93,365 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24