Cenpj MGI Mouse Gene Detail - MGI:2684927

Symbol

Cenpj
Name

centromere protein J
Synonyms

4932437H03Rik, Sas4

Feature Type

protein coding gene
IDs

MGI:2684927
NCBI Gene: 219103
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:56764218-56812882 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.28 cM
Mapping Data

1 experiment

SNPs within 2kb

1002 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684927	protein coding gene	Chr14:56764218-56812950 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021394	protein coding gene	Chr14:50617813-50666773 (-)
A/J	MGP_AJ_G0021353	protein coding gene	Chr14:49612588-49660375 (-)
AKR/J	MGP_AKRJ_G0021329	protein coding gene	Chr14:51408785-51455661 (-)
BALB/cJ	MGP_BALBcJ_G0021356	protein coding gene	Chr14:49603385-49647502 (-)
C3H/HeJ	MGP_C3HHeJ_G0021137	protein coding gene	Chr14:51053926-51099865 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021796	protein coding gene	Chr14:53146090-53192990 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019338	protein coding gene	Chr14:47771026-47812035 (-)
CAST/EiJ	MGP_CASTEiJ_G0020656	protein coding gene	Chr14:47368790-47422502 (-)
CBA/J	MGP_CBAJ_G0021104	protein coding gene	Chr14:54725466-54772753 (-)
DBA/2J	MGP_DBA2J_G0021224	protein coding gene	Chr14:49330222-49373198 (-)
FVB/NJ	MGP_FVBNJ_G0021207	protein coding gene	Chr14:48718519-48761782 (-)
LP/J	MGP_LPJ_G0021299	protein coding gene	Chr14:51683445-51732014 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021231	protein coding gene	Chr14:54116295-54166719 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021822	protein coding gene	Chr14:50535231-50584503 (-)
PWK/PhJ	MGP_PWKPhJ_G0020399	protein coding gene	Chr14:45847494-45897025 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020229	protein coding gene	Chr14:46602123-46651686 (-)
WSB/EiJ	MGP_WSBEiJ_G0020708	protein coding gene	Chr14:50874422-50925781 (-)

Human Ortholog

CPAP, centrosome assembly and centriole elongation protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPAP, centrosome assembly and centriole elongation protein
Synonyms

BM032, CENP-J, CENPJ, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4
Links

HGNC:17272

NCBI Gene ID: 55835

neXtProt AC: NX_Q9HC77

UniProt: Q9HC77
Chr Location

13q12.12-q12.13; chr13:24882279-24934000 (-) GRCh38

MGI Vertebrate Homology

Cenpj stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CPAP
Gene Tree

Cenpj

Diseases

1 with Cenpj mouse models; 3 with human CPAP associations

Human Disease

Mouse Models

Seckel syndrome

IDs

View 1 model

primary autosomal recessive microcephaly

IDs

primary autosomal recessive microcephaly 6

IDs

Seckel syndrome 4

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

82 phenotypes from 5 alleles in 5 genetic backgrounds
7 phenotypes from multigenic genotypes
3 images
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Gene trapped

3
Targeted

6
Genomic Mutations

1 involving Cenpj
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for null alleles exhibit embryonic lethality during early organogenesis and may show failure of embryo turning and absence of centrioles, cilia and centrosomes. Mice homozygous for a hypomorphic allele display partial lethality, dwarfism and a wide range of abnormalities.

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All GO Annotations

52
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

26
cDNA Data

43
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cenpj

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All Sequences

44
RefSeq

8
UniProt

3
CCDS

CCDS27150.1

Ensembl

ENSMUSG00000064128 (Evidence)
NCBI Gene

219103

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064128	Ensembl Gene Model \| MGI Sequence Detail	48665	C57BL/6J	± kb
transcript	ENSMUST00000065302	Ensembl \| MGI Sequence Detail	4363	Not Applicable
polypeptide	ENSMUSP00000065949	Ensembl \| MGI Sequence Detail	1344	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005330 centromere protein J

(term hierarchy)
InterPro Domains

IPR009852 Centromere protein J, C-terminal domain

IPR047002 T-complex protein 10, C-terminal domain superfamily

IPR026581 T-complex protein 10 family

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All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 2

Summaries

All 57

Developmental Gene Expression 12

Diseases 1

Gene Ontology 12

Phenotypes 24
Earliest

J:78713 Peng B, et al., CPAP Is a Novel Stat5-Interacting Cofactor that Augments Stat5-Mediated Transcriptional Activity. Mol Endocrinol. 2002 Sep;16(9):2019-33
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cenpj:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128931	Chr14:56812918-56812939 (-)	-47 bp
Tssr128930	Chr14:56809287-56809317 (-)	3,580 bp
Tssr128929	Chr14:56809265-56809277 (-)	3,611 bp
Tssr128928	Chr14:56789496-56789528 (-)	23,370 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24