Dcaf13 MGI Mouse Gene Detail - MGI:2684929 - DDB1 and CUL4 associated factor 13

Symbol

Dcaf13
Name

DDB1 and CUL4 associated factor 13
Synonyms

LOC223499, Wdsof1

Feature Type

protein coding gene
IDs

MGI:2684929
NCBI Gene: 223499
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:38976300-39010251 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 15.42 cM
Mapping Data

1 experiment

SNPs within 2kb

381 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684929	protein coding gene	Chr15:38976260-39010251 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021814	protein coding gene	Chr15:37534220-37569961 (+)
A/J	MGP_AJ_G0021774	protein coding gene	Chr15:36084257-36123039 (+)
AKR/J	MGP_AKRJ_G0021755	protein coding gene	Chr15:37161114-37195370 (+)
BALB/cJ	MGP_BALBcJ_G0021781	protein coding gene	Chr15:36120096-36156554 (+)
C3H/HeJ	MGP_C3HHeJ_G0021555	protein coding gene	Chr15:37090850-37125204 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022220	protein coding gene	Chr15:38975483-39011420 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019757	protein coding gene	Chr15:33836252-33870264 (+)
CAST/EiJ	MGP_CASTEiJ_G0021072	protein coding gene	Chr15:37530599-37567051 (+)
CBA/J	MGP_CBAJ_G0021524	protein coding gene	Chr15:40332274-40377032 (+)
DBA/2J	MGP_DBA2J_G0021648	protein coding gene	Chr15:35912598-35945869 (+)
FVB/NJ	MGP_FVBNJ_G0021626	protein coding gene	Chr15:35319393-35353151 (+)
LP/J	MGP_LPJ_G0021718	protein coding gene	Chr15:37402520-37440358 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021650	protein coding gene	Chr15:43205574-43244721 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022243	protein coding gene	Chr15:37289727-37331213 (+)
PWK/PhJ	MGP_PWKPhJ_G0020817	protein coding gene	Chr15:35973308-36008889 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020654	protein coding gene	Chr15:36982658-37017480 (+)
WSB/EiJ	MGP_WSBEiJ_G0021127	protein coding gene	Chr15:37231838-37264424 (+)

Human Ortholog

DCAF13, DDB1 and CUL4 associated factor 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF13, DDB1 and CUL4 associated factor 13
Synonyms

GM83, HSPC064, Sof1, WDSOF1
Links

HGNC:24535

NCBI Gene ID: 25879

neXtProt AC: NX_Q9NV06

UniProt: Q9NV06
Chr Location

8q22.3; chr8:103414714-103443453 (+) GRCh38

MGI Vertebrate Homology

Dcaf13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCAF13
Gene Tree

Dcaf13

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Phenotype Summary

23 phenotypes from 2 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

6
Targeted

2
Genomic Mutations

2 involving Dcaf13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit pre-implantation lethality with failure of morula compaction.

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All GO Annotations

33
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

12
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf13

ZFIN dcaf13

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All Sequences

41
RefSeq

4
UniProt

1
CCDS

CCDS37066.1

Ensembl

ENSMUSG00000022300 (Evidence)
NCBI Gene

223499

			Length	Strain/Species	Flank
genomic	223499	NCBI Gene Model \| MGI Sequence Detail	33952	C57BL/6J	± kb
transcript	NM_198606	RefSeq \| MGI Sequence Detail	1511	C57BL/6
polypeptide	Q6PAC3	UniProt \| EBI \| MGI Sequence Detail	445	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017402 DDB1- and CUL4-associated factor 13

(term hierarchy)
InterPro Domains

IPR007287 Sof1-like protein

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR051733 WD repeat-containing DCAF13/WDSOF1

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345635 Zhou L, et al., T cell proliferation requires ribosomal maturation in nucleolar condensates dependent on DCAF13. J Cell Biol. 2023 Oct 2;222(10)

TSS for Dcaf13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131136	Chr15:38976263-38976310 (+)	-13 bp
Tssr131137	Chr15:38976318-38976330 (+)	24 bp
Tssr131138	Chr15:38976337-38976344 (+)	41 bp
Tssr131139	Chr15:38976346-38976355 (+)	51 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24