Gxylt1 MGI Mouse Gene Detail - MGI:2684933 - glucoside xylosyltransferase 1

Symbol

Gxylt1
Name

glucoside xylosyltransferase 1
Synonyms

Glt8d3, LOC223827, LOC382997

Feature Type

protein coding gene
IDs

MGI:2684933
NCBI Gene: 223827
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:93137623-93173060 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 47.34 cM
Mapping Data

4 experiments

SNPs within 2kb

975 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684933	protein coding gene	Chr15:93137611-93173060 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022253	protein coding gene	Chr15:94640710-94679146 (-)
A/J	MGP_AJ_G0022212	protein coding gene	Chr15:90971700-91020460 (-)
AKR/J	MGP_AKRJ_G0022187	protein coding gene	Chr15:93697252-93738299 (-)
BALB/cJ	MGP_BALBcJ_G0022218	protein coding gene	Chr15:91106395-91142001 (-)
C3H/HeJ	MGP_C3HHeJ_G0021988	protein coding gene	Chr15:93706611-93749457 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022663	protein coding gene	Chr15:98098350-98136385 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020189	protein coding gene	Chr15:87028575-87062627 (-)
CAST/EiJ	MGP_CASTEiJ_G0021510	protein coding gene	Chr15:94527585-94564123 (-)
CBA/J	MGP_CBAJ_G0021955	protein coding gene	Chr15:101423593-101463963 (-)
DBA/2J	MGP_DBA2J_G0022082	protein coding gene	Chr15:90415073-90451232 (-)
FVB/NJ	MGP_FVBNJ_G0022061	protein coding gene	Chr15:89437871-89473466 (-)
LP/J	MGP_LPJ_G0022153	protein coding gene	Chr15:94752872-94789874 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022081	protein coding gene	Chr15:105779520-105817954 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022678	protein coding gene	Chr15:93782064-93820012 (-)
PWK/PhJ	MGP_PWKPhJ_G0021251	protein coding gene	Chr15:90463215-90500824 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021085	protein coding gene	Chr15:93528340-93561727 (-)
WSB/EiJ	MGP_WSBEiJ_G0021559	protein coding gene	Chr15:94278795-94315335 (-)

Human Ortholog

GXYLT1, glucoside xylosyltransferase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GXYLT1, glucoside xylosyltransferase 1
Synonyms

GLT8D3
Links

HGNC:27482

NCBI Gene ID: 283464

neXtProt AC: NX_Q4G148

UniProt: Q4G148
Chr Location

12q12; chr12:42081845-42144874 (-) GRCh38

MGI Vertebrate Homology

Gxylt1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GXYLT1
Gene Tree

Gxylt1

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Gxylt1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

76

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gxylt1

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All Sequences

47
RefSeq

7
UniProt

2
CCDS

CCDS27764.1, CCDS84189.1, CCDS88828.1

Ensembl

ENSMUSG00000036197 (Evidence)
NCBI Gene

223827

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036197	Ensembl Gene Model \| MGI Sequence Detail	35438	C57BL/6J	± kb
transcript	ENSMUST00000057896	Ensembl \| MGI Sequence Detail	1891	Not Applicable
polypeptide	ENSMUSP00000081947	Ensembl \| MGI Sequence Detail	435	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030306 glucoside xylosyltransferase 1

(term hierarchy)
EC

2.4.2.42
InterPro Domains

IPR051993 Glycosyltransferase 8

IPR002495 Glycosyl transferase, family 8

IPR029044 Nucleotide-diphospho-sugar transferases
GlyGen

Q3UHH8 3 sites, 5 N-linked glycans (3 sites)

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All nucleic 76

cDNA 76

Microarray probesets 3

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MGI:2686074

Summaries

All 57

Diseases 1

Gene Ontology 6

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gxylt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135964	Chr15:93173035-93173059 (-)	13 bp
Tssr135963	Chr15:93173003-93173024 (-)	46 bp
Tssr135962	Chr15:93168482-93168489 (-)	4,574 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24