Arhgap30 MGI Mouse Gene Detail - MGI:2684948 - Rho GTPase activating protein 30

Symbol

Arhgap30
Name

Rho GTPase activating protein 30
Synonyms

6030405P05Rik

Feature Type

protein coding gene
IDs

MGI:2684948
NCBI Gene: 226652
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr1:171216528-171237808 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.39 cM
Mapping Data

1 experiment

SNPs within 2kb

685 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684948	protein coding gene	Chr1:171216522-171237866 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016760	protein coding gene	Chr1:177189610-177211762 (+)
A/J	MGP_AJ_G0016740	protein coding gene	Chr1:169965181-169986572 (+)
AKR/J	MGP_AKRJ_G0016706	protein coding gene	Chr1:175060141-175082324 (+)
BALB/cJ	MGP_BALBcJ_G0016701	protein coding gene	Chr1:170460086-170481826 (+)
C3H/HeJ	MGP_C3HHeJ_G0016524	protein coding gene	Chr1:175314743-175336156 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017162	protein coding gene	Chr1:183079780-183102941 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014870	protein coding gene	Chr1:161653944-161675421 (+)
CAST/EiJ	MGP_CASTEiJ_G0016105	protein coding gene	Chr1:174936977-174959830 (+)
CBA/J	MGP_CBAJ_G0016499	protein coding gene	Chr1:189587305-189608573 (+)
DBA/2J	MGP_DBA2J_G0016606	protein coding gene	Chr1:168807876-168829474 (+)
FVB/NJ	MGP_FVBNJ_G0016602	protein coding gene	Chr1:167159419-167180710 (+)
LP/J	MGP_LPJ_G0016677	protein coding gene	Chr1:178300883-178322292 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016629	protein coding gene	Chr1:196865639-196887031 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017199	protein coding gene	Chr1:174929712-174951102 (+)
PWK/PhJ	MGP_PWKPhJ_G0015891	protein coding gene	Chr1:168030932-168052528 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015675	protein coding gene	Chr1:173720765-173741953 (+)
WSB/EiJ	MGP_WSBEiJ_G0016167	protein coding gene	Chr1:175048039-175070968 (+)

Human Ortholog

ARHGAP30, Rho GTPase activating protein 30

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP30, Rho GTPase activating protein 30
Links

HGNC:27414

NCBI Gene ID: 257106

neXtProt AC: NX_Q7Z6I6

UniProt: Q7Z6I6
Chr Location

1q23.3; chr1:161046946-161069970 (-) GRCh38

MGI Vertebrate Homology

Arhgap30 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGAP30
Gene Tree

Arhgap30

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

2
Targeted

2
Genomic Mutations

2 involving Arhgap30
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

27

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgap30

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS15494.1

Ensembl

ENSMUSG00000048865 (Evidence)
NCBI Gene

226652

			Length	Strain/Species	Flank
genomic	226652	NCBI Gene Model \| MGI Sequence Detail	21281	C57BL/6J	± kb
transcript	NM_001005508	RefSeq \| MGI Sequence Detail	4509	C57BL/6
polypeptide	Q640N3	UniProt \| EBI \| MGI Sequence Detail	1101	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004236 Rho GTPase-activating protein 30

(term hierarchy)
InterPro Domains

IPR051576 PX Domain-Containing Rho GAP

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein
GlyGen

Q640N3 1 site, 1 O-linked glycan (1 site)

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All nucleic 27

cDNA 27

Microarray probesets 2

Summaries

All 33

Gene Ontology 4

Phenotypes 13
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgap30:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10032	Chr1:171216488-171216503 (+)	-32 bp
Tssr10033	Chr1:171216523-171216610 (+)	39 bp
Tssr10034	Chr1:171216636-171216667 (+)	124 bp
Tssr10035	Chr1:171216668-171216683 (+)	148 bp
Tssr10036	Chr1:171216698-171216705 (+)	174 bp
Tssr10037	Chr1:171216714-171216725 (+)	192 bp
Tssr10038	Chr1:171216749-171216765 (+)	229 bp
Tssr10039	Chr1:171216779-171216801 (+)	262 bp
Tssr10040	Chr1:171216808-171216815 (+)	284 bp
Tssr10041	Chr1:171230765-171230814 (+)	14,262 bp
Tssr10042	Chr1:171235470-171235479 (+)	18,947 bp
Tssr10043	Chr1:171235585-171235602 (+)	19,066 bp
Tssr10044	Chr1:171235681-171235701 (+)	19,163 bp
Tssr10045	Chr1:171235728-171235746 (+)	19,209 bp
Tssr10046	Chr1:171235747-171235765 (+)	19,228 bp
Tssr10047	Chr1:171235778-171235790 (+)	19,256 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24