Man1b1 MGI Mouse Gene Detail - MGI:2684954 - mannosidase, alpha, class 1B, member 1

Symbol

Man1b1
Name

mannosidase, alpha, class 1B, member 1
Synonyms

E430019H13Rik, LOC227619, MANA-ER

Feature Type

protein coding gene
IDs

MGI:2684954
NCBI Gene: 227619
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:25222742-25242225 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.17 cM
Mapping Data

1 experiment

SNPs within 2kb

494 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684954	protein coding gene	Chr2:25222350-25242225 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025439	protein coding gene	Chr2:23206086-23229841 (+)
A/J	MGP_AJ_G0025416	protein coding gene	Chr2:22314720-22335122 (+)
AKR/J	MGP_AKRJ_G0025386	protein coding gene	Chr2:23061441-23083574 (+)
BALB/cJ	MGP_BALBcJ_G0025412	protein coding gene	Chr2:22425230-22446092 (+)
C3H/HeJ	MGP_C3HHeJ_G0025173	protein coding gene	Chr2:22988485-23014831 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025856	protein coding gene	Chr2:23948383-23974247 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023267	protein coding gene	Chr2:21226978-21246725 (+)
CAST/EiJ	MGP_CASTEiJ_G0024636	protein coding gene	Chr2:22870806-22893273 (+)
CBA/J	MGP_CBAJ_G0025151	protein coding gene	Chr2:24774458-24801145 (+)
DBA/2J	MGP_DBA2J_G0025284	protein coding gene	Chr2:22154980-22174611 (+)
FVB/NJ	MGP_FVBNJ_G0025246	protein coding gene	Chr2:21896197-21916402 (+)
LP/J	MGP_LPJ_G0025370	protein coding gene	Chr2:23151028-23171785 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025277	protein coding gene	Chr2:24978239-24999742 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025915	protein coding gene	Chr2:23006797-23028384 (+)
PWK/PhJ	MGP_PWKPhJ_G0024384	protein coding gene	Chr2:21970162-21990688 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024184	protein coding gene	Chr2:23157115-23177673 (+)
WSB/EiJ	MGP_WSBEiJ_G0024705	protein coding gene	Chr2:23077718-23098300 (+)

Human Ortholog

MAN1B1, mannosidase alpha class 1B member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAN1B1, mannosidase alpha class 1B member 1
Synonyms

ERMAN1, ERManI, MANA-ER, MRT15
Links

HGNC:6823

NCBI Gene ID: 11253

neXtProt AC: NX_Q9UKM7

UniProt: Q9UKM7
Chr Location

9q34.3; chr9:137086857-137109189 (+) GRCh38

MGI Vertebrate Homology

Man1b1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAN1B1
Gene Tree

Man1b1

Diseases

1 with human MAN1B1 associations

				Human Disease	Mouse Models
				Rafiq syndrome IDs Rafiq syndrome DOID:0081097 OMIM:614202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

85
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase man1b1

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All Sequences

65
RefSeq

6
UniProt

6
CCDS

CCDS15765.1

Ensembl

ENSMUSG00000036646 (Evidence)
NCBI Gene

227619

			Length	Strain/Species	Flank
genomic	227619	NCBI Gene Model \| MGI Sequence Detail	19484	C57BL/6J	± kb
transcript	NM_001029983	RefSeq \| MGI Sequence Detail	3748	C57BL/6
polypeptide	A2AJ15	UniProt \| EBI \| MGI Sequence Detail	658	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010103 endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

(term hierarchy)
EC

3.2.1.-, 3.2.1.113
InterPro Domains

IPR001382 Glycoside hydrolase family 47

IPR050749 Glycosyl Hydrolase Family 47

IPR036026 Seven-hairpin glycosidases

IPR012341 Six-hairpin glycosidase-like superfamily

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All nucleic 86

cDNA 85

Primer pair 1

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Man1b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16697	Chr2:25222234-25222259 (+)	-495 bp
Tssr16698	Chr2:25222744-25222794 (+)	27 bp
Tssr16699	Chr2:25222807-25222825 (+)	74 bp
Tssr16700	Chr2:25231727-25231731 (+)	8,987 bp
Tssr16701	Chr2:25236286-25236293 (+)	13,548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24