Mms22l MGI Mouse Gene Detail - MGI:2684980 - MMS22-like, DNA repair protein

Symbol

Mms22l
Name

MMS22-like, DNA repair protein
Synonyms

F730047E07Rik

Feature Type

protein coding gene
IDs

MGI:2684980
NCBI Gene: 212377
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr4:24496451-24602950 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 10.36 cM
Mapping Data

1 experiment

SNPs within 2kb

2828 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684980	protein coding gene	Chr4:24496451-24602950 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028098	protein coding gene	Chr4:21601973-21712644 (+)
A/J	MGP_AJ_G0028056	protein coding gene	Chr4:20958589-21064981 (+)
AKR/J	MGP_AKRJ_G0028021	protein coding gene	Chr4:21426535-21542458 (+)
BALB/cJ	MGP_BALBcJ_G0028067	protein coding gene	Chr4:21019211-21130319 (+)
C3H/HeJ	MGP_C3HHeJ_G0027797	protein coding gene	Chr4:21611413-21740916 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028510	protein coding gene	Chr4:22496313-22617333 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025852	protein coding gene	Chr4:19452245-19556864 (+)
CAST/EiJ	MGP_CASTEiJ_G0027252	protein coding gene	Chr4:21335683-21484188 (+)
CBA/J	MGP_CBAJ_G0027770	protein coding gene	Chr4:23167745-23279630 (+)
DBA/2J	MGP_DBA2J_G0027913	protein coding gene	Chr4:20848702-20973204 (+)
FVB/NJ	MGP_FVBNJ_G0027879	protein coding gene	Chr4:20510013-20616832 (+)
LP/J	MGP_LPJ_G0028022	protein coding gene	Chr4:21706976-21816013 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027912	protein coding gene	Chr4:24610991-24728757 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028569	protein coding gene	Chr4:21409872-21516515 (+)
PWK/PhJ	MGP_PWKPhJ_G0026972	protein coding gene	Chr4:20589029-20720345 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026801	protein coding gene	Chr4:21153770-21262785 (+)
WSB/EiJ	MGP_WSBEiJ_G0027329	protein coding gene	Chr4:21338806-21452426 (+)

Human Ortholog

MMS22L, MMS22 like, DNA repair protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMS22L, MMS22 like, DNA repair protein
Synonyms

C6orf167, dJ39B17.2
Links

HGNC:21475

NCBI Gene ID: 253714

neXtProt AC: NX_Q6ZRQ5

UniProt: Q6ZRQ5
Chr Location

6q16.1; chr6:97142161-97284035 (-) GRCh38

MGI Vertebrate Homology

Mms22l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MMS22L
Gene Tree

Mms22l

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Phenotype Summary

3 phenotypes from 1 allele in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

4
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation die prenatally. Heterozygous mice exhibit defects in pinna responses.

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All GO Annotations

26
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

54
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mms22l

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All Sequences

76
RefSeq

16
UniProt

8
CCDS

CCDS18006.2

Ensembl

ENSMUSG00000045751 (Evidence)
NCBI Gene

212377

			Length	Strain/Species	Flank
genomic	212377	NCBI Gene Model \| MGI Sequence Detail	106500	C57BL/6J	± kb
transcript	NR_149739	RefSeq \| MGI Sequence Detail	4735	C57BL/6
polypeptide	B1AUR6	UniProt \| EBI \| MGI Sequence Detail	1238	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000032683 protein MMS22-like

(term hierarchy)
InterPro Domains

IPR029424 MMS22-like, C-terminal

IPR042320 Protein MMS22-like

IPR029425 Protein MMS22-like, N-terminal

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All nucleic 54

cDNA 54

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mms22l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36636	Chr4:24496434-24496499 (+)	16 bp
Tssr36637	Chr4:24556692-24556701 (+)	60,246 bp
Tssr36638	Chr4:24585464-24585478 (+)	89,020 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24