Asap3 MGI Mouse Gene Detail - MGI:2684986 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

Symbol

Asap3
Name

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms

9430088F20Rik, Ddefl1, UPLC1

Feature Type

protein coding gene
IDs

MGI:2684986
NCBI Gene: 230837
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:135933676-135972527 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 68.34 cM
Mapping Data

2 experiments

SNPs within 2kb

1328 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684986	protein coding gene	Chr4:135933662-135973888 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028962	protein coding gene	Chr4:138737473-138777620 (+)
A/J	MGP_AJ_G0028921	protein coding gene	Chr4:132839694-132878385 (+)
AKR/J	MGP_AKRJ_G0028873	protein coding gene	Chr4:136679974-136723546 (+)
BALB/cJ	MGP_BALBcJ_G0028945	protein coding gene	Chr4:133501494-133540903 (+)
C3H/HeJ	MGP_C3HHeJ_G0028659	protein coding gene	Chr4:136956960-136996540 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029386	protein coding gene	Chr4:143656493-143706169 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026657	protein coding gene	Chr4:125875426-125913835 (+)
CAST/EiJ	MGP_CASTEiJ_G0028091	protein coding gene	Chr4:135097273-135137966 (+)
CBA/J	MGP_CBAJ_G0028624	protein coding gene	Chr4:147590052-147640405 (+)
DBA/2J	MGP_DBA2J_G0028773	protein coding gene	Chr4:133257007-133296005 (+)
FVB/NJ	MGP_FVBNJ_G0028740	protein coding gene	Chr4:132200685-132239538 (+)
LP/J	MGP_LPJ_G0028872	protein coding gene	Chr4:138827882-138871414 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028766	protein coding gene	Chr4:151835335-151885153 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029424	protein coding gene	Chr4:137137977-137177603 (+)
PWK/PhJ	MGP_PWKPhJ_G0027811	protein coding gene	Chr4:130030896-130071045 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027637	protein coding gene	Chr4:132958402-132998683 (+)
WSB/EiJ	MGP_WSBEiJ_G0028169	protein coding gene	Chr4:137305441-137348679 (+)

Human Ortholog

ASAP3, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASAP3, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms

ACAP4, CENTB6, DDEFL1, UPLC1
Links

HGNC:14987

NCBI Gene ID: 55616

neXtProt AC: NX_Q8TDY4

UniProt: Q8TDY4
Chr Location

1p36.12; chr1:23428563-23484637 (-) GRCh38

MGI Vertebrate Homology

Asap3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ASAP3
Gene Tree

Asap3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

4
Targeted

2
Genomic Mutations

3 involving Asap3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

31

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asap3

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All Sequences

39
RefSeq

9
UniProt

2
CCDS

CCDS18802.1

Ensembl

ENSMUSG00000036995 (Evidence)
NCBI Gene

230837

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036995	Ensembl Gene Model \| MGI Sequence Detail	38852	C57BL/6J	± kb
transcript	ENSMUST00000047526	Ensembl \| MGI Sequence Detail	4225	Not Applicable
polypeptide	ENSMUSP00000041899	Ensembl \| MGI Sequence Detail	904	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004340 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR043593 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein

IPR001164 Arf GTPase activating protein

IPR028775 Arf GTPase activating protein 3, BAR domain

IPR047006 ASAP3, ArfGAP domain

IPR037844 ASAP, PH domain

IPR004148 BAR domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 31

cDNA 31

Microarray probesets 2

Summaries

All 36

Gene Ontology 5

Phenotypes 13
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Asap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39689	Chr4:135933690-135933716 (+)	27 bp
Tssr39690	Chr4:135933722-135933765 (+)	68 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24