About   Help   FAQ
Asap3 Gene Detail
Summary
  • Symbol
    Asap3
  • Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
  • Synonyms
    9430088F20Rik, Ddefl1, UPLC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684986
    NCBI Gene: 230837
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135933676-135972527 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684986
 protein coding gene Chr4:135933662-135973888 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028962
 protein coding gene Chr4:138737473-138777620 (+)
A/J MGP_AJ_G0028921
 protein coding gene Chr4:132839694-132878385 (+)
AKR/J MGP_AKRJ_G0028873
 protein coding gene Chr4:136679974-136723546 (+)
BALB/cJ MGP_BALBcJ_G0028945
 protein coding gene Chr4:133501494-133540903 (+)
C3H/HeJ MGP_C3HHeJ_G0028659
 protein coding gene Chr4:136956960-136996540 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029386
 protein coding gene Chr4:143656493-143706169 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026657
 protein coding gene Chr4:125875426-125913835 (+)
CAST/EiJ MGP_CASTEiJ_G0028091
 protein coding gene Chr4:135097273-135137966 (+)
CBA/J MGP_CBAJ_G0028624
 protein coding gene Chr4:147590052-147640405 (+)
DBA/2J MGP_DBA2J_G0028773
 protein coding gene Chr4:133257007-133296005 (+)
FVB/NJ MGP_FVBNJ_G0028740
 protein coding gene Chr4:132200685-132239538 (+)
LP/J MGP_LPJ_G0028872
 protein coding gene Chr4:138827882-138871414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028766
 protein coding gene Chr4:151835335-151885153 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029424
 protein coding gene Chr4:137137977-137177603 (+)
PWK/PhJ MGP_PWKPhJ_G0027811
 protein coding gene Chr4:130030896-130071045 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027637
 protein coding gene Chr4:132958402-132998683 (+)
WSB/EiJ MGP_WSBEiJ_G0028169
 protein coding gene Chr4:137305441-137348679 (+)



Homology
more
  • Human Ortholog
    ASAP3, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASAP3, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
  • Synonyms
    ACAP4, CENTB6, DDEFL1, UPLC1
  • Links
    NCBI Gene ID: 55616
    neXtProt AC: NX_Q8TDY4
    UniProt: Q8TDY4

  • Chr Location
    1p36.12; chr1:23428563-23484637 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    31
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036995 Ensembl Gene Model | MGI Sequence Detail 38852 C57BL/6J ±  kb
transcript ENSMUST00000047526 Ensembl | MGI Sequence Detail 4225 Not Applicable  
polypeptide ENSMUSP00000041899 Ensembl | MGI Sequence Detail 904 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory