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Cytl1 Gene Detail
Summary
  • Symbol
    Cytl1
  • Name
    cytokine-like 1
  • Synonyms
    4930443F05Rik, C17
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684993
    NCBI Gene: 231162
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:37892863-37897164 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 20.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684993
 protein coding gene Chr5:37892863-37897164 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029503
 protein coding gene Chr5:36114598-36118934 (+)
A/J MGP_AJ_G0029469
 protein coding gene Chr5:34918769-34923010 (+)
AKR/J MGP_AKRJ_G0029419
 protein coding gene Chr5:36226877-36231116 (+)
BALB/cJ MGP_BALBcJ_G0029480
 protein coding gene Chr5:35406885-35411113 (+)
C3H/HeJ MGP_C3HHeJ_G0029203
 protein coding gene Chr5:36229407-36234832 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029934
 protein coding gene Chr5:38055226-38059508 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027172
 protein coding gene Chr5:32607913-32612449 (+)
CAST/EiJ MGP_CASTEiJ_G0028611
 protein coding gene Chr5:35391640-35395978 (+)
CBA/J MGP_CBAJ_G0029170
 protein coding gene Chr5:38927586-38935588 (+)
DBA/2J MGP_DBA2J_G0029317
 protein coding gene Chr5:35037502-35041788 (+)
FVB/NJ MGP_FVBNJ_G0029276
 protein coding gene Chr5:34513437-34517681 (+)
LP/J MGP_LPJ_G0029403
 protein coding gene Chr5:36568067-36572331 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029306
 protein coding gene Chr5:39673203-39680270 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029967
 protein coding gene Chr5:35726718-35732826 (+)
PWK/PhJ MGP_PWKPhJ_G0028335
 protein coding gene Chr5:34208951-34213587 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028168
 protein coding gene Chr5:35179059-35183351 (+)
WSB/EiJ MGP_WSBEiJ_G0028692
 protein coding gene Chr5:35806940-35812398 (+)



Homology
more
  • Human Ortholog
    CYTL1, cytokine like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYTL1, cytokine like 1
  • Synonyms
    C17, C4orf4
  • Links
    NCBI Gene ID: 54360
    neXtProt AC: NX_Q9NRR1
    UniProt: Q9NRR1

  • Chr Location
    4p16.2; chr4:5014586-5019458 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to osteoarthritic cartilage destruction following destabilization of the medial meniscus surgery.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    994
  • Tissues
    74
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231162 NCBI Gene Model | MGI Sequence Detail 4302 C57BL/6J ±  kb
    transcript NM_001081106 RefSeq | MGI Sequence Detail 974 Not Specified  
    polypeptide NP_001074575 RefSeq | MGI Sequence Detail 139 Not Specified  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR029253 Cytokine-like protein 1
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 4
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory