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Tlcd5 Gene Detail
Summary
  • Symbol
    Tlcd5
  • Name
    TLC domain containing 5
  • Synonyms
    LOC235300, Tmem136
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685030
    NCBI Gene: 235300
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:43019945-43027865 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685030
 protein coding gene Chr9:43019945-43028000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034681
 protein coding gene Chr9:41490218-41498902 (-)
A/J MGP_AJ_G0034661
 protein coding gene Chr9:40381295-40389324 (-)
AKR/J MGP_AKRJ_G0034587
 protein coding gene Chr9:41162927-41172231 (-)
BALB/cJ MGP_BALBcJ_G0034652
 protein coding gene Chr9:40107558-40115328 (-)
C3H/HeJ MGP_C3HHeJ_G0034363
 protein coding gene Chr9:41656998-41665505 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035175
 protein coding gene Chr9:42750586-42758322 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032088
 protein coding gene Chr9:39990269-39997793 (-)
CAST/EiJ MGP_CASTEiJ_G0033686
 protein coding gene Chr9:41462535-41472954 (-)
CBA/J MGP_CBAJ_G0034336
 protein coding gene Chr9:44265399-44273159 (-)
DBA/2J MGP_DBA2J_G0034495
 protein coding gene Chr9:40293389-40301136 (-)
FVB/NJ MGP_FVBNJ_G0034435
 protein coding gene Chr9:39528634-39536412 (-)
LP/J MGP_LPJ_G0034576
 protein coding gene Chr9:41776367-41786332 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034479
 protein coding gene Chr9:46210419-46217987 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035194
 protein coding gene Chr9:41073977-41081715 (-)
PWK/PhJ MGP_PWKPhJ_G0033391
 protein coding gene Chr9:40139065-40147151 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033227
 protein coding gene Chr9:41361689-41370639 (-)
WSB/EiJ MGP_WSBEiJ_G0033799
 protein coding gene Chr9:41123279-41131039 (-)



Homology
more
  • Human Ortholog
    TLCD5, TLC domain containing 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLCD5, TLC domain containing 5
  • Synonyms
    TMEM136
  • Links
    NCBI Gene ID: 219902
    neXtProt AC: NX_Q6ZRR5
    UniProt: Q6ZRR5

  • Chr Location
    11q23.3; chr11:120325296-120333686 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    29
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048503 Ensembl Gene Model | MGI Sequence Detail 7921 C57BL/6J ±  kb
transcript ENSMUST00000061833 Ensembl | MGI Sequence Detail 3503 Not Applicable  
polypeptide ENSMUSP00000051435 Ensembl | MGI Sequence Detail 245 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
Other
Accession IDs
less
MGI:3528940, MGI:6369425
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 11
  • Earliest
    J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory