Pik3c2b MGI Mouse Gene Detail - MGI:2685045 - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

Symbol

Pik3c2b
Name

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms

C330011J12Rik, PI3K-C2beta

Feature Type

protein coding gene
IDs

MGI:2685045
NCBI Gene: 240752
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:132973410-133036429 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.75 cM
Mapping Data

1 experiment

SNPs within 2kb

1755 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685045	protein coding gene	Chr1:132973405-133036429 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016479	protein coding gene	Chr1:136556770-136621008 (+)
A/J	MGP_AJ_G0016462	protein coding gene	Chr1:131497078-131561764 (+)
AKR/J	MGP_AKRJ_G0016427	protein coding gene	Chr1:135362059-135434427 (+)
BALB/cJ	MGP_BALBcJ_G0016422	protein coding gene	Chr1:131831075-131894302 (+)
C3H/HeJ	MGP_C3HHeJ_G0016248	protein coding gene	Chr1:135506609-135572504 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016883	protein coding gene	Chr1:141631253-141698855 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014594	protein coding gene	Chr1:124656260-124719417 (+)
CAST/EiJ	MGP_CASTEiJ_G0015828	protein coding gene	Chr1:134529152-134597751 (+)
CBA/J	MGP_CBAJ_G0016220	protein coding gene	Chr1:146451748-146524495 (+)
DBA/2J	MGP_DBA2J_G0016327	protein coding gene	Chr1:130458199-130523551 (+)
FVB/NJ	MGP_FVBNJ_G0016326	protein coding gene	Chr1:129107233-129170542 (+)
LP/J	MGP_LPJ_G0016398	protein coding gene	Chr1:137876119-137939040 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016351	protein coding gene	Chr1:152233255-152298406 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016919	protein coding gene	Chr1:135120358-135184781 (+)
PWK/PhJ	MGP_PWKPhJ_G0015614	protein coding gene	Chr1:129464235-129529850 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015401	protein coding gene	Chr1:134075443-134140212 (+)
WSB/EiJ	MGP_WSBEiJ_G0015890	protein coding gene	Chr1:135122431-135188063 (+)

Human Ortholog

PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms

C2-PI3K
Links

HGNC:8972

NCBI Gene ID: 5287

neXtProt AC: NX_O00750

UniProt: O00750
Chr Location

1q32.1; chr1:204422628-204494805 (-) GRCh38

MGI Vertebrate Homology

Pik3c2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIK3C2B
Gene Tree

Pik3c2b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
21 phenotype references

All Mutations and Alleles

19
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

1
Targeted

8
Genomic Mutations

3 involving Pik3c2b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

82 strains or lines available

Mice homozygous for a knock-out allele exhibit normal epidermal growth, differentiation and function.

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All GO Annotations

22
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

96
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pik3c2b

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All Sequences

44
RefSeq

9
UniProt

4
CCDS

CCDS48360.1

Ensembl

ENSMUSG00000026447 (Evidence)
NCBI Gene

240752

			Length	Strain/Species	Flank
genomic	240752	NCBI Gene Model \| MGI Sequence Detail	63020	C57BL/6J	± kb
transcript	NM_001099276	RefSeq \| MGI Sequence Detail	7929	C57BL/6
polypeptide	NP_001092746	RefSeq \| MGI Sequence Detail	1632	C57BL/6

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UniProt

4 Sequences
InterPro Domains

IPR016024 Armadillo-type fold

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR002420 C2 phosphatidylinositol 3-kinase-type domain

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain

IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

IPR018936 Phosphatidylinositol 3/4-kinase, conserved site

IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain

IPR042134 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, PX domain

IPR015433 Phosphatidylinositol kinase

IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain

IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

IPR001683 Phox homology

IPR011009 Protein kinase-like domain superfamily

IPR036871 PX domain superfamily

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 16

cDNA 16

Microarray probesets 1

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 21
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:341022 Massana-Munoz X, et al., Inactivating the lipid kinase activity of PI3KC2beta is sufficient to rescue myotubular myopathy in mice. JCI Insight. 2023 May 8;8(9)

TSS for Pik3c2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8760	Chr1:132973722-132973820 (+)	361 bp
Tssr208	Chr1:132973823-132973836 (+)	420 bp
Tssr8761	Chr1:132973881-132973900 (+)	481 bp
Tssr8762	Chr1:132973902-132973925 (+)	504 bp
Tssr8763	Chr1:132973929-132973944 (+)	527 bp
Tssr8764	Chr1:132981038-132981065 (+)	7,642 bp
Tssr8765	Chr1:132996219-132996232 (+)	22,816 bp
Tssr8766	Chr1:132996237-132996251 (+)	22,834 bp
Tssr8767	Chr1:133011890-133011903 (+)	38,487 bp
Tssr8768	Chr1:133020023-133020036 (+)	46,620 bp
Tssr209	Chr1:133026382-133026393 (+)	52,978 bp
Tssr8769	Chr1:133031276-133031302 (+)	57,879 bp
Tssr8770	Chr1:133035867-133035875 (+)	62,461 bp
Tssr8771	Chr1:133036133-133036138 (+)	62,726 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24